ATI RN
Safety Pharmacology Across the Lifespan Questions
Question 1 of 5
Which of the following drug treatment strategies is associated with peptic ulcer disease?
Correct Answer: C
Rationale: The correct answer is C: Antibiotics (amoxicillin and clarithromycin). Peptic ulcer disease is often caused by Helicobacter pylori infection, which can be effectively treated with antibiotics such as amoxicillin and clarithromycin. Opioids (A) can lead to constipation but are not directly associated with peptic ulcers. Corticosteroids (B) can worsen peptic ulcer disease by inhibiting prostaglandin synthesis. Hormonal therapy (D) is not typically associated with peptic ulcers. Antibiotics directly target the underlying cause of peptic ulcers, making them the most appropriate treatment strategy.
Question 2 of 5
What makes Losartan different from other ARBs?
Correct Answer: C
Rationale: Losartan is different from other ARBs because it undergoes hepatic metabolism to form an active metabolite, which contributes significantly to its pharmacological effects. This active metabolite, known as E-3174, has a longer half-life compared to Losartan itself, making its duration of action more sustained. Choices A, B, and D are incorrect because Losartan does not have the shortest half-life, does not have a small volume of distribution, and is primarily metabolized by the liver rather than being renally eliminated.
Question 3 of 5
Which of the following just rug strategies is associated with peptic ulcer disease?
Correct Answer: C
Rationale: The correct answer is C: Antibiotics (amoxicillin and clarithromycin). Peptic ulcer disease is commonly caused by Helicobacter pylori bacteria, which can be treated with a combination of antibiotics such as amoxicillin and clarithromycin. Corticosteroids (choice A) and hormonal therapy (choice B) are not typically associated with treating the underlying cause of peptic ulcers. Opioids (choice D) can actually exacerbate peptic ulcer disease by increasing gastric acid secretion. Therefore, choice C is the most appropriate treatment strategy for peptic ulcer disease due to its ability to target and eliminate the bacterial infection causing the ulcers.
Question 4 of 5
Your patient is allergic to penicillin and sulfa medications. Which antibiotic can be given safely to the patient?
Correct Answer: C
Rationale: Step 1: Patient allergic to penicillin and sulfa, ruling out choices A, B, and D which contain cephalosporins. Step 2: Zithromycin (Choice C) is a macrolide antibiotic, unrelated to penicillin or sulfa, making it safe for the patient. Summary: A, B, and D are incorrect due to containing cephalosporins, which can cross-react with penicillin allergy. Choice C (Zithromycin) is the correct answer as it is a safe alternative for the patient with penicillin and sulfa allergies.
Question 5 of 5
A 17 year old asthmatic patient has been told that marijuana may help with his anxiety. Which adverse effect has been associated with marijuana and may be a reason for this patient to avoid use of marijuana?
Correct Answer: A
Rationale: The correct answer is A: Short term memory loss. Marijuana has been associated with impairing short-term memory due to its effects on the brain's hippocampus. This may be concerning for the 17-year-old asthmatic patient as it can affect cognitive function, learning, and overall daily functioning. Other choices are incorrect: B: Hepatitis is not directly associated with marijuana use. C: Hyperthermia is more commonly linked to stimulant drug use rather than marijuana. D: Hyponatremia is not a well-known adverse effect of marijuana.