Which of the following conditions is not treated with Methotrexate?

Correct Answer: D

Rationale: The correct answer is D: Rheumatic fever. Methotrexate is not typically used to treat rheumatic fever as it is an autoimmune inflammatory condition, not typically responsive to Methotrexate. Methotrexate is commonly used to treat sarcomas, leukemias, and ectopic pregnancies due to its ability to inhibit cell proliferation. Sarcomas and leukemias are types of cancers, while ectopic pregnancy is a condition where a fertilized egg implants outside the uterus.

Correct Answer: D

Rationale: Explanation: Dexamethasone is a corticosteroid used to treat inflammation and conditions like asthma and Addison's disease, which involve inflammation or immune responses. Wilson's disease is a genetic disorder related to copper metabolism, not treated with Dexamethasone. Dexamethasone could worsen Wilson's disease due to its potential impact on copper levels.

Correct Answer: C

Rationale: Rationale: Lansoprazole is a proton pump inhibitor used to reduce stomach acid production. Hypertension is a condition related to high blood pressure and is not treated with Lansoprazole. Zollinger-Ellison syndrome, gastritis, and reflux are all conditions that can be treated with Lansoprazole due to its ability to reduce stomach acid. Therefore, choice C is the correct answer.

Correct Answer: A

Rationale: Protamine is the antidote for Heparin toxicity because it binds to Heparin and forms a stable complex, neutralizing its anticoagulant effects. Protamine sulfate is positively charged, while Heparin is negatively charged, allowing them to bind effectively. Methylene blue is used to treat methemoglobinemia, not Heparin toxicity. N-acetylcysteine is used for acetaminophen overdose, and Glucagon is used for beta-blocker overdose.

Correct Answer: D

Rationale: The correct answer is D: Penicillamine. Penicillamine is a chelating agent that binds to copper and forms a complex that can be excreted from the body, making it an effective antidote for copper toxicity. Glucagon (A) is used for treating hypoglycemia, aminocaproic acid (B) is used to treat excessive bleeding, and atropine (C) is used to treat bradycardia and organophosphate poisoning, none of which are related to copper toxicity.