Which of the following conditions is not treated with Dexamethasone?

Correct Answer: D

Rationale: Explanation: Dexamethasone is a corticosteroid used to treat inflammation and conditions like asthma and Addison's disease, which involve inflammation or immune responses. Wilson's disease is a genetic disorder related to copper metabolism, not treated with Dexamethasone. Dexamethasone could worsen Wilson's disease due to its potential impact on copper levels.

Correct Answer: D

Rationale: The correct answer is D: Hyperactivity. Clozapine is an antipsychotic drug used for schizophrenia treatment. Agranulocytosis is a known severe side effect of Clozapine. Hyperactivity is not a known effect of Clozapine, as it actually has a sedative effect due to its mechanism of action in the brain. Therefore, option D is the correct answer. Options A, B, and C are incorrect as agranulocytosis is a known side effect, Clozapine is an antipsychotic drug, and it is commonly used for schizophrenia treatment.

Correct Answer: B

Rationale: The correct answer is B: Liver. Warfarin is primarily metabolized in the liver by the cytochrome P450 enzyme system. The liver is responsible for breaking down and activating many drugs, including Warfarin. It is where the drug's metabolism and effects are most significant. The other choices are incorrect because Warfarin's main site of activity is in the liver, not the kidney, blood, or heart. The kidney mainly excretes the drug, while the blood carries it throughout the body, and the heart is not directly involved in Warfarin's metabolism.

Correct Answer: D

Rationale: Explanation: Dexamethasone is a corticosteroid used to treat inflammation and conditions like asthma and Addison's disease, which involve inflammation or immune responses. Wilson's disease is a genetic disorder related to copper metabolism, not treated with Dexamethasone. Dexamethasone could worsen Wilson's disease due to its potential impact on copper levels.

Correct Answer: A

Rationale: The correct answer is A: Flumazenil. Flumazenil is a specific benzodiazepine receptor antagonist that can reverse the effects of benzodiazepine toxicity by competitively inhibiting the binding of benzodiazepines to their receptors. It works by reversing the sedative and respiratory depressant effects of benzodiazepines. Methylene blue (B) is used to treat methemoglobinemia, not benzodiazepine toxicity. Deferoxamine (C) is used for iron toxicity. Alkalinizing urine (D) is used to enhance the excretion of weak acids in the urine, not for benzodiazepine toxicity.

Correct Answer: D

Rationale: The correct answer is D: Fluoroquinolones. Fluoroquinolones are known to be associated with tendon dysfunction due to their potential to cause tendinitis and tendon rupture. This adverse effect is thought to be related to the drug's ability to disrupt collagen synthesis and structure in tendons. Digitalis (A) is used to treat heart conditions, niacin (B) for cholesterol, and tetracycline (C) for bacterial infections, none of which are linked to tendon dysfunction.

Correct Answer: D

Rationale: The correct answer is D: Rheumatic fever. Methotrexate is not typically used to treat rheumatic fever as it is an autoimmune inflammatory condition, not typically responsive to Methotrexate. Methotrexate is commonly used to treat sarcomas, leukemias, and ectopic pregnancies due to its ability to inhibit cell proliferation. Sarcomas and leukemias are types of cancers, while ectopic pregnancy is a condition where a fertilized egg implants outside the uterus.

Correct Answer: D

Rationale: The correct answer is D: Procainamide. Procainamide is a class IA antiarrhythmic drug that blocks sodium channels, prolonging the action potential duration. This helps to stabilize the heart's rhythm. Mexiletine (A) is a class IB antiarrhythmic drug that blocks sodium channels with fast recovery kinetics. Amiodarone (B) is a class III antiarrhythmic drug that prolongs repolarization by blocking potassium channels. Quinidine (C) is a class IA antiarrhythmic drug that also blocks sodium channels, but it is not a class IB sodium channel blocker like Procainamide.

Correct Answer: B

Rationale: The correct answer is B: Protease inhibitor. Drugs ending in the suffix (navir) are commonly used to inhibit protease enzymes in viruses, particularly in the treatment of HIV/AIDS. Protease inhibitors disrupt viral replication by preventing the cleavage of viral proteins, thus inhibiting the production of new infectious viral particles. Choice A, Antidepressant, is incorrect as drugs used to treat depression usually end in (ine) or (pram). Choice C, Beta antagonist, is incorrect as drugs affecting beta receptors typically end in (olol) or (lol). Choice D, H antagonist, is incorrect as drugs targeting histamine receptors usually end in (ine) or (idine).