Which of the following can be used for specific prophylaxis of pertussis?

Correct Answer: A

Rationale: The correct answer is A: Pertussis toxoid. This is because pertussis toxoid is a component of the pertussis vaccine, which provides specific prophylaxis against pertussis by stimulating the immune system to produce antibodies against the bacteria causing the disease. Choice B, killed vaccine, is incorrect as it does not specify pertussis toxoid. Choice C, wide-spectrum antibiotics, is incorrect as antibiotics are used for treatment, not prophylaxis. Choice D, None of the above, is incorrect as pertussis toxoid is specifically used for prophylaxis of pertussis.

Correct Answer: A

Rationale: The correct answer is A: Aspergillosis and candidiasis. Galactomannan is a polysaccharide found in Aspergillus cell walls and is detected in patients with invasive aspergillosis. Free mannan is a polysaccharide found in Candida cell walls and is detected in patients with candidiasis. Therefore, detection of galactomannan and free mannan is specific for diagnosing Aspergillosis and candidiasis. Choices B, C, and D are incorrect as HIV infection, syphilis, and leptospirosis do not involve the detection of galactomannan or free mannan for diagnosis.

Correct Answer: B

Rationale: The correct answer is B because in immune reactions, a large lattice is formed when antigens and antibodies are in optimal proportion. This optimal ratio allows for the formation of a strong antigen-antibody complex, leading to the aggregation of immune complexes into large lattice structures. When antibodies are in excess (choice A), there may not be enough antigens to form a stable lattice. Similarly, when antigens are in excess (choice C), there may be insufficient antibodies to form a strong lattice. Choice D is incorrect because the optimal proportion of antigens and antibodies is crucial for the formation of large lattices in immune reactions.

Correct Answer: D

Rationale: The correct answer is D: Relenza and Tamiflu. Both Relenza and Tamiflu are anti-influenza drugs that target the neuraminidase enzyme of the influenza virus, thereby inhibiting its replication and spread. Maxi Grip (A) is not an anti-influenza drug, Theraflu (B) contains different active ingredients, and Amantadine and Rimantadine (C) target a different viral protein, M2 ion channel. Therefore, choices A, B, and C are incorrect as they do not specifically target neuraminidase for influenza treatment.

Correct Answer: A

Rationale: The correct answer is A: Acid resistance. Tuberculous bacilli are acid-fast bacilli, meaning they resist decolorization by acid-alcohol after staining with Ziehl-Neelsen stain. This property is due to the high lipid content in the cell wall of Mycobacterium tuberculosis. Alkali resistance (B) and alcohol resistance (C) are not specific properties of tuberculous bacilli. Capsule formation (D) is a characteristic of some bacteria but is not a defining feature of tuberculous bacilli.

Correct Answer: D

Rationale: Step 1: The symptoms of optic nerve neuritis, memory impairment, and cramps are indicative of ethambutol toxicity. Step 2: Ethambutol is known to cause optic nerve toxicity leading to neuritis, as well as CNS toxicity causing memory impairment. Step 3: Ethambutol can also lead to peripheral neuropathy manifesting as cramps. Step 4: Isoniazid is associated with peripheral neuropathy and hepatotoxicity but not with optic nerve neuritis or memory impairment. Step 5: PASA is not commonly used for tuberculosis treatment and does not cause the described symptoms. Step 6: Rifampicin is known for hepatotoxicity and flu-like symptoms, but not specifically for optic nerve neuritis, memory impairment, or cramps. Summary: Ethambutol is the correct answer due to its known side effects of optic nerve toxicity, CNS toxicity, and peripheral neuropathy, which align with the presented symptoms. Ison

Correct Answer: A

Rationale: The correct answer is A: Chingamin (also known as Chloroquine). Chingamin is the drug of choice for chemoprophylaxis of malaria in regions with high risk. It is effective against Plasmodium falciparum, the most common malaria parasite. Chingamin is well-tolerated, affordable, and has a long track record of use. Sulfalen (Choice B) is not commonly used for malaria prophylaxis. Tetracycline (Choice C) is not recommended for malaria prophylaxis due to poor efficacy and resistance development. Metronidazole (Choice D) is not effective against malaria parasites.

Correct Answer: A

Rationale: The correct answer is A: Mycobacterium tuberculosis. This bacteria is responsible for causing tuberculosis because it is the specific pathogen known to infect the lungs and other parts of the body, leading to the disease. Mycobacterium tuberculosis has unique cell wall components that allow it to evade the immune system and survive in the host. Neisseria meningitidis (B) causes meningitis, not tuberculosis. Salmonella enterica (C) causes food poisoning, not tuberculosis. Streptococcus pneumoniae (D) causes pneumonia, not tuberculosis. Therefore, the correct answer is A based on the specific characteristics and pathogenicity of Mycobacterium tuberculosis.

Correct Answer: C

Rationale: Plasmids often carry antibiotic resistance genes, making choice C correct. Plasmids are circular DNA structures, not linear (A). They are found in both gram-positive and gram-negative bacteria, not exclusively in gram-positive bacteria (B). Plasmids are separate from the bacterial chromosome, not part of it (D). Therefore, choice C is the correct answer.