Which of the following bunyaviruses is not arthropod-borne?

Correct Answer: B

Rationale: The correct answer is B: Hantavirus. Hantaviruses are not arthropod-borne, unlike the other choices. Hantaviruses are transmitted to humans primarily through contact with rodent urine, feces, or saliva. Phlebovirus (A), Nairovirus (C), and Uukuvirus (D) are all bunyaviruses that are transmitted by arthropod vectors such as mosquitoes or ticks. Therefore, Hantavirus is the correct answer as it is not transmitted by arthropods.

Correct Answer: A

Rationale: The correct answer is A: Yersinia pestis. Y. pestis is a Gram-negative rod that exhibits a 'safety pin' appearance on staining due to bipolar staining. This bacterium is the causative agent of plague, which can present as painful ulcers known as buboes. Y. pestis is transmitted by fleas and can cause outbreaks in humans. Summary: - B: Francisella tularensis causes tularemia, not typically associated with painful ulcers. - C: Brucella abortus causes brucellosis, which does not typically present with painful ulcers. - D: Clostridium botulinum causes botulism, characterized by muscle weakness and paralysis, not painful ulcers.

Correct Answer: A

Rationale: Step 1: Gram-positive cocci in grape-like clusters suggest Staphylococcus. Step 2: Catalase-positive indicates Staphylococcus (negative for Streptococcus). Step 3: Coagulase-positive is specific for Staphylococcus aureus. Summary: B: Streptococcus pyogenes is catalase-negative. C: Enterococcus faecalis does not form grape-like clusters. D: Micrococcus luteus is catalase-positive but not coagulase-positive.

Correct Answer: B

Rationale: Memory cells are not part of the non-specific immune response because they are a component of the specific immune response. Non-specific immune responses are immediate and target a broad range of pathogens, whereas memory cells are formed after exposure to a specific pathogen to provide a quicker and stronger response upon subsequent exposure. Lysozyme (A), Interferon (C), and Phagocytosis (D) are all part of the non-specific immune response. Lysozyme is an enzyme that destroys bacterial cell walls, interferon helps to inhibit viral replication, and phagocytosis involves the engulfing and destruction of pathogens by phagocytes. These responses are not specific to particular pathogens and are the body's first line of defense.

Correct Answer: A

Rationale: The correct answer is A: Neutralization reaction. This is the most appropriate serological test to reveal botulinum toxin because it involves mixing the patient's serum with known botulinum antitoxin. If the patient's serum contains botulinum toxin, it will neutralize the antitoxin, leading to a lack of toxin-neutralizing ability. The other choices are incorrect because agglutination reaction involves clumping of cells, not suitable for detecting botulinum toxin; Bordet-Gengou test is used to detect antibodies in pertussis infection, not botulinum toxin; and precipitation reaction involves the formation of a solid when two solutions are mixed, not ideal for detecting botulinum toxin.

Correct Answer: B

Rationale: The correct answer is B: Gamma globulin, as it is not a primary immunodeficiency disease. Primary immunodeficiency diseases are genetic disorders that affect the immune system's ability to fight infections. A: Glanzmann-Riniker hypergammaglobulinemia is a rare primary immunodeficiency characterized by elevated levels of gammaglobulins. C: Variable hypogammaglobulinemia is a primary immunodeficiency disease where there are fluctuating levels of gammaglobulins. D: Bruton hypogammaglobulinemia, also known as X-linked agammaglobulinemia, is a primary immunodeficiency characterized by a lack of B cells and gammaglobulins. In summary, B is the correct answer as gamma globulin is not a primary immunodeficiency disease, whereas A, C, and D are all examples of primary immunodeficiency diseases affecting gammaglobulins levels.

Correct Answer: A

Rationale: The correct answer is A: ocular lens. The ocular lens is the lens closest to the eye in a compound light microscope. This lens is responsible for magnifying the image produced by the objective lens. It typically has a magnification power of 10x. The objective lens, choice B, is positioned closer to the specimen and provides the primary magnification of the image. The condenser, choice C, is located beneath the stage and helps focus light onto the specimen. The stage, choice D, is where the specimen is placed for observation. Therefore, the ocular lens is the correct choice as it is the lens closest to the eye and responsible for further magnifying the image.

Correct Answer: B

Rationale: The correct answer is B because the main target of the toxin produced by Vibrio cholerae is the epithelial cells of the small intestine. This toxin, known as cholera toxin, binds to the surface of these cells and disrupts their normal function, leading to the characteristic watery diarrhea seen in cholera. The other choices are incorrect because macrophages are not the main target, RBCs are not directly affected by the toxin, and the stomach epithelial cells are not specifically targeted by Vibrio cholerae toxin.

Correct Answer: B

Rationale: The correct answer is B: Diarrhea. Brucellosis typically presents with symptoms such as arthralgia, headache, and undulating fever, but diarrhea is not a common symptom associated with the disease. Brucellosis is primarily characterized by systemic symptoms like fever, joint pain, and headache due to the bacterial infection. Diarrhea is more commonly seen in gastrointestinal infections rather than brucellosis. Therefore, the absence of diarrhea as a symptom in brucellosis helps in differentiating it from other diseases with similar clinical presentations.