ATI RN
Endocrine Pharmacology NCLEX Questions Questions
Question 1 of 5
Which of the following best explains the primary reason for careful adjustment of the levothyroxine dose during pregnancy?
Correct Answer: D
Rationale: The correct answer is D: Better gastrointestinal absorption. During pregnancy, there are physiological changes that affect drug absorption. Levothyroxine requires careful adjustment because gastrointestinal absorption can be altered, leading to fluctuations in serum levels. Ensuring optimal absorption helps maintain stable thyroid hormone levels for maternal and fetal health. Rationale for why the other choices are incorrect: A: Longer half-life is not the primary reason for dose adjustment during pregnancy, as the concern lies more with absorption changes. B: Less frequent adverse effects do not drive the need for dose adjustment in pregnancy; it is about maintaining stable hormone levels. C: Higher affinity for thyroid receptors is not the primary factor driving dose adjustments; absorption is key to ensuring adequate hormone levels.
Question 2 of 5
Which of the following actions was most likely to contribute to the therapeutic effect of prednisone in the patient's Crohn disease?
Correct Answer: A
Rationale: The correct answer is A: Increased catabolism of prostaglandins. Prednisone is a corticosteroid that exerts its therapeutic effect by suppressing the immune response and reducing inflammation. Prostaglandins are lipid compounds that promote inflammation. Prednisone works by inhibiting the production of prostaglandins, leading to decreased inflammation in Crohn's disease. Choice B: Decreased number of circulating neutrophils is incorrect because prednisone may decrease neutrophil count, but this is not the primary mechanism of action in treating Crohn's disease. Choice C: Increased proliferation of T cells is incorrect as prednisone actually suppresses T cell proliferation, which is beneficial in controlling inflammation in Crohn's disease. Choice D: Increased activation of complement system is incorrect as prednisone does not directly affect the complement system. The main mechanism of action lies in its ability to suppress inflammation by inhibiting prostaglandin synthesis.
Question 3 of 5
Which of the following drugs would be most appropriate for this patient with metastatic cancer?
Correct Answer: A
Rationale: Rationale: Anastrozole is an aromatase inhibitor used for hormone receptor-positive metastatic breast cancer. It inhibits estrogen synthesis, slowing cancer growth. Flutamide is for prostate cancer. Mifepristone is for abortion and Cushing's syndrome, not cancer. Ethinyl estradiol is a synthetic estrogen and not used for cancer.
Question 4 of 5
A 43-year-old woman recently diagnosed with endometriosis started a treatment with medroxyprogesterone, one tablet daily. Which of the following effects most likely occurred after a few days of therapy?
Correct Answer: A
Rationale: The correct answer is A: Decreased body temperature. Medroxyprogesterone is a progestin that can suppress ovulation and reduce estrogen levels. Estrogen influences thermoregulation, so a decrease in estrogen levels can lead to a lower body temperature. The other choices are incorrect because B: increased estrogen secretion would be unlikely with progestin treatment, C: increased ventilatory response to carbon dioxide is not a typical effect of medroxyprogesterone, and D: decreased kidney excretion of sodium and water is not directly related to this medication.
Question 5 of 5
A young couple presented to the physician complaining that they have been trying for 2 years to conceive a second child but have not been successful. Their first child was a healthy 4-year-old girl. Lab tests revealed that the husband was severely oligospermic. On questioning, he admitted he had been taking some drugs to aid his athletic performance. Which of the following drugs most likely contributed to the oligospermia of this man?
Correct Answer: B
Rationale: The correct answer is B: Danazol. Danazol is an androgen derivative that can suppress testosterone production, leading to oligospermia. This drug is known to have negative effects on sperm production and fertility. In this case, the husband's use of drugs to aid athletic performance likely included danazol, which contributed to his oligospermia. Choice A: Vitamin B12 is not known to cause oligospermia. It is essential for sperm production and overall reproductive health. Choice C: Ferrous sulphate is a form of iron supplement and is not associated with oligospermia. It is used to treat iron deficiency anemia. Choice D: Medroxyprogesterone is a progestin hormone and is not a known cause of oligospermia. It is used for various medical conditions but does not directly impact sperm production.