Which of the following bacteria is responsible for causing the disease known as tetanus?

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Question 1 of 9

Which of the following bacteria is responsible for causing the disease known as tetanus?

Correct Answer: A

Rationale: The correct answer is A: Clostridium tetani. Clostridium tetani is responsible for causing tetanus by producing a neurotoxin called tetanospasmin. This neurotoxin blocks inhibitory signals in the central nervous system, leading to muscle spasms and stiffness characteristic of tetanus. Clostridium perfringens (B) causes gas gangrene, Streptococcus pyogenes (C) causes strep throat, and Escherichia coli (D) can cause gastrointestinal infections but not tetanus. Therefore, based on the specific pathogen and its mechanism of action, Clostridium tetani is the correct answer.

Question 2 of 9

Patient with diarrhoea was admitted to the infection unit. Gram-negative curved rod-like bacteria were founded on bacterioscopic examination of faecal masses. What is the most likely disease in this patient?

Correct Answer: B

Rationale: The correct answer is B: Cholera. Cholera is caused by Gram-negative curved rod-like bacteria called Vibrio cholerae, commonly found in contaminated water or food. The characteristic symptom of cholera is profuse watery diarrhea, which matches the patient's presentation. Typhoid fever (A) is caused by Salmonella typhi, which is not a curved rod-like bacteria. Diphtheria (C) is caused by Corynebacterium diphtheriae, a Gram-positive bacterium, and does not typically cause diarrhea. Intestinal form of plague (D) is caused by Yersinia pestis, which is not a curved rod-like bacteria and does not typically present with diarrhea.

Question 3 of 9

A patient with dysentery had a stool sample that was cultured on Endo agar, resulting in colorless colonies. The bacteria were Gram-negative rods. What is the most likely causative agent?

Correct Answer: A

Rationale: Rationale: 1. Endo agar inhibits the growth of Gram-positive bacteria. 2. Colorless colonies on Endo agar indicate lactose non-fermenting bacteria. 3. Shigella dysenteriae is a lactose non-fermenting, Gram-negative rod, causing dysentery. 4. Salmonella typhi, Escherichia coli, and Proteus vulgaris are lactose fermenters, so they would produce pink colonies on Endo agar. Therefore, the most likely causative agent is Shigella dysenteriae.

Question 4 of 9

Which one is true about the laboratory diagnosis of urinary tract infections

Correct Answer: D

Rationale: The correct answer is D because it encompasses the true statements regarding the laboratory diagnosis of urinary tract infections. A: Bacteriuria of less than 10^5 can be significant in treated patients due to the development of antibiotic resistance. B: Staphylococcus aureus, Salmonella typhi, and Mycobacterium tuberculosis may be significant regardless of quantity due to their pathogenic nature. C: Leukocyturia indicates inflammation, and even a lower number of leukocytes can be clinically significant. Therefore, option D covers all these aspects making it the correct choice.

Question 5 of 9

In a maternity hospital a newborn should receive vaccination against tuberculosis. What vaccine should be chosen?

Correct Answer: A

Rationale: The correct answer is A: BCG vaccine. Step 1: BCG vaccine is specifically designed to protect against tuberculosis, making it the appropriate choice for newborns. Step 2: STI vaccine is for sexually transmitted infections, not tuberculosis. Step 3: EV vaccine is not a recognized vaccine. Step 4: DPT vaccine protects against diphtheria, pertussis, and tetanus, not tuberculosis. In summary, BCG vaccine is the correct choice as it targets tuberculosis specifically, while the other options are designed for different purposes.

Question 6 of 9

The capsule of the bacteria is composed of:

Correct Answer: B

Rationale: The correct answer is B because the capsule of bacteria is mainly composed of polysaccharides or polypeptides. This outer layer helps bacteria evade the host's immune system and protects them from desiccation. Peptidoglycan (choice A) is a component of the bacterial cell wall, not the capsule. Flagellin (choice C) is a protein component of the bacterial flagella, not the capsule. Choice D is incorrect as the capsule is indeed composed of polysaccharides or polypeptides.

Question 7 of 9

A 14-year-old boy was diagnosed with Hutchinson's triad: barrel-shaped teeth, parenchymatous keratitis, and deafness. These signs are characteristic of:

Correct Answer: A

Rationale: The correct answer is A: Syphilis. Hutchinson's triad is a classic presentation of congenital syphilis. Barrel-shaped teeth, parenchymatous keratitis, and deafness are hallmark signs. These occur due to infection of the fetus by the spirochete Treponema pallidum. Syphilis can lead to various systemic manifestations, including skeletal abnormalities, skin lesions, and neurological complications. Opisthorchiasis, Toxoplasmosis, and Tuberculosis do not typically present with the specific triad described in the question. Opisthorchiasis is a parasitic infection, Toxoplasmosis is caused by a protozoan, and Tuberculosis is a bacterial infection that primarily affects the lungs.

Question 8 of 9

Which bacteria are responsible for causing meningitis?

Correct Answer: D

Rationale: The correct answer is D. Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae are all known to cause meningitis. Neisseria meningitidis is a common cause of bacterial meningitis in young adults. Haemophilus influenzae is a leading cause of meningitis in children, and Streptococcus pneumoniae is a common cause in adults. Therefore, all three bacteria are responsible for causing meningitis, making option D the correct choice. Option A, B, and C are incorrect because they each represent only one of the bacteria responsible for causing meningitis, while option D includes all three.

Question 9 of 9

48 hours after performing tuberculin test (Mantoux test) to a child a 10 mm papule appeared on the spot of tuberculin introduction. What hypersensitivity mechanism underlies these changes?

Correct Answer: D

Rationale: The correct answer is D: Granulomatosis. The appearance of a 10 mm papule 48 hours after the Mantoux test indicates a delayed-type hypersensitivity reaction, which is characteristic of granulomatosis. This type of reaction involves activation of macrophages and T cells, leading to the formation of granulomas. Granulomas are organized collections of immune cells that wall off the antigen, in this case, the tuberculin antigen. A, B, and C are incorrect: A: Cellular cytotoxicity involves the destruction of target cells by immune cells such as cytotoxic T cells or natural killer cells. This mechanism is not associated with the delayed-type hypersensitivity reaction seen in granulomatosis. B: Anaphylaxis is a rapid and severe allergic reaction involving IgE-mediated release of histamine and other inflammatory mediators. This is not the mechanism underlying the delayed-type hypersensitivity reaction in the Mantoux test. C: Antibody-dependent cytotoxic

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