Which of the following are the four categories of pharmacokinetics?

Correct Answer: C

Rationale: Pharmacokinetics comprises absorption (entry to blood), distribution (to tissues), metabolism (chemical change), and excretion (removal)-standard categories tracking a drug's journey. Others mix processes or invent terms (e.g., interspersing), lacking precision. These four define the field, essential for dosing and effect.

Correct Answer: A

Rationale: Lithium is commonly used as a mood stabilizer in the treatment of bipolar disorder. One of its main therapeutic effects is its ability to prevent or decrease the incidence of acute manic episodes in individuals with bipolar disorder. Lithium can help stabilize mood swings and reduce the severity and frequency of manic episodes. By regulating neurotransmitter levels in the brain, lithium helps to balance mood and prevent the extreme highs associated with mania. It is an essential medication for managing bipolar disorder and is particularly effective in treating manic symptoms.

Correct Answer: B

Rationale: Interleukin 2 is administered intravenously because it is a protein that would be broken down in the digestive system if taken orally. Epoetin alfa, granulocyte colony–stimulating factor (G-CSF), and granulocyte-macrophage colony–stimulating factor (GM-CSF) can be administered subcutaneously. The nurse should ensure proper administration of interleukin 2 and monitor for side effects, such as capillary leak syndrome, which can cause fluid retention and hypotension.

Correct Answer: D

Rationale: Antiepileptics vary in side effects. Valproate causes tremor or hepatotoxicity, not visual defects. Carbamazepine risks rash or hyponatremia, not eyes. Lamotrigine is linked to rash, tiagabine to dizziness, without visual impact. Vigabatrin, a GABA-transaminase inhibitor, causes irreversible concentric visual field defects in ~30-40% of users due to retinal toxicity, a unique and serious adverse effect. This necessitates ophthalmologic monitoring, distinguishing it in epilepsy treatment choices.

Correct Answer: C

Rationale: Irradiation of donor blood is a standard practice to prevent graft-versus-host disease (GVHD) in immunocompromised patients. Irradiation inactivates the donor's lymphocytes, preventing them from attacking the recipient's tissues. Diphenhydramine and acetaminophen are used to manage allergic reactions or fever but do not prevent GVHD. Administering the transfusion slowly does not address the risk of GVHD. Therefore, irradiation is the correct preventive measure.