ATI RN
Endocrine Pharmacology Quiz Questions
Question 1 of 5
Which of the following are incorrectly paired?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Which adverse effect would be expected during therapy with leuprolide for a woman with endometriosis?
Correct Answer: D
Rationale: Leuprolide is a GnRH agonist commonly used to treat endometriosis by inducing a temporary menopause-like state. Hot flushes are a common adverse effect due to the sudden decrease in estrogen levels. This is the expected side effect as the drug suppresses ovarian function. Galactorrhea is unlikely as it is more associated with prolactin-related issues. Vaginal infections are not directly related to leuprolide therapy for endometriosis. Menorrhagia is also unlikely as leuprolide suppresses menstruation. Therefore, hot flushes are the correct adverse effect to expect during therapy.
Question 3 of 5
Which of the following drugs would be most appropriate for the boy diagnosed with Laron dwarfism?
Correct Answer: C
Rationale: The correct answer is C: Mecasermin. This drug is a recombinant human insulin-like growth factor-1 (IGF-1) and is used to treat Laron dwarfism, a condition characterized by IGF-1 deficiency. Mecasermin directly targets the underlying cause of the condition by providing the necessary growth factor. A: Somatropin is recombinant human growth hormone and is not as effective in treating Laron dwarfism as it primarily targets the growth hormone pathway. B: Octreotide is a somatostatin analog used to treat conditions like acromegaly, not Laron dwarfism. D: Oxandrolone is an anabolic steroid that may help increase growth in some cases, but it does not directly address the underlying cause of Laron dwarfism like Mecasermin does.
Question 4 of 5
Which of the following drugs should be administered first to control hormone-related effects that could be rapidly lethal in this patient?
Correct Answer: B
Rationale: Step 1: Identify the rapidly lethal hormone-related effects – likely thyroid storm. Step 2: Propranolol is a beta-blocker that helps control symptoms like tachycardia and hypertension in thyroid storm, making it crucial for immediate management. Step 3: Betamethasone (A) is a corticosteroid, not the first-line for thyroid storm. Potassium iodide (C) is used for thyroid blockade in radiation emergencies, not initial treatment. Propylthiouracil (D) is used for long-term management but not the initial control of symptoms.
Question 5 of 5
Inhibition of which of the following enzymes most likely mediated the therapeutic effect of the drug in the patient's disease?
Correct Answer: D
Rationale: The correct answer is D: Stimulation of thyroid peroxidase. In the patient's disease, a drug would likely be used to increase thyroid hormone production. Thyroid peroxidase plays a crucial role in thyroid hormone synthesis by catalyzing the iodination of tyrosine residues on thyroglobulin. By stimulating thyroid peroxidase activity, the drug can enhance thyroid hormone production. The other choices (A, B, C) are incorrect because inhibiting thyroid protease, topoisomerase I, or proteolysis of thyroglobulin would not directly impact thyroid hormone synthesis and, therefore, would not likely mediate the therapeutic effect in the patient's disease.