Which of the following antifungal agent act as fungicidal by inhibiting the * synthesis of β1,3 glucan used for the disseminated mucocutaneous Candida infections?

Correct Answer: A

Rationale: Rationale: Caspofungin is a echinocandin antifungal that inhibits the synthesis of β1,3 glucan in the fungal cell wall, leading to cell death. This mechanism makes it fungicidal against Candida infections. Amphotericin B disrupts fungal cell membranes, while Flucytosine interferes with DNA/RNA synthesis. Ketoconazole inhibits ergosterol synthesis. Therefore, A is correct as it targets the specific mechanism for Candida infections.

Correct Answer: A

Rationale: The correct answer is A: Furosemide. Aminoglycoside antibiotics can cause ototoxicity and nephrotoxicity. Furosemide, a loop diuretic, also has the potential to cause ototoxicity and nephrotoxicity, leading to a serious side effect when combined with aminoglycosides. On the other hand, choices B, C, and D (Hydrochlorothiazide, Spironolactone, and Acetazolamide) do not share the same serious side effects with aminoglycosides. Hydrochlorothiazide is a thiazide diuretic that acts on the distal convoluted tubule, Spironolactone is a potassium-sparing diuretic that acts on the collecting duct, and Acetazolamide is a carbonic anhydrase inhibitor diuretic that works in the proximal tubule. Therefore, Furosemide should

Correct Answer: C

Rationale: Rationale: Intravenous Plain NSS infusion is the treatment of choice for dilutional hyponatremia, which can occur as a complication of furosemide therapy due to excessive diuresis leading to low sodium levels. This solution helps restore normal sodium levels without affecting the fluid balance. Summary: A: Hypokalemia - Furosemide therapy can cause hypokalemia, which is usually treated with potassium supplements, not NSS infusion. B: Severe dehydration - NSS infusion may be used for severe dehydration but is not specific to furosemide therapy complications. D: None of the above - Incorrect, as C is the correct answer for dilutional hyponatremia.

Correct Answer: B

Rationale: The correct answer is B: albumin. Glomerular capillaries have a filtration barrier that prevents large molecules like albumin from passing into the filtrate. Water (A), urea (C), and sodium ions (D) are smaller molecules that can pass through the filtration barrier and are normally found in the filtrate. Albumin, being a large protein molecule, is normally retained in the blood and not expected to appear in the filtrate. This is essential for maintaining proper blood composition and oncotic pressure.

Correct Answer: C

Rationale: The correct answer is C: Being female. Being female does not increase the risk of developing a UTI. UTIs are more common in females due to shorter urethras. Pregnancy (A) can increase UTI risk due to hormonal changes. Diabetes mellitus (B) can affect the immune system, leading to higher UTI susceptibility. Catheterization (D) introduces bacteria into the urinary tract, significantly increasing the risk of UTIs. Overall, being female alone does not directly increase the risk of UTIs compared to the other factors mentioned.