Which of the following antidiabetic drugs is most suitable for treatment of diabetes during pregnancy?

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Clomiphene (choice A), a selective estrogen receptor modulator (SERM), induces ovulation by blocking estrogen receptors in the hypothalamus and pituitary, diminishing negative feedback. This increases gonadotropin (FSH/LH) release, stimulating ovarian follicle development, crucial for infertility treatment. Increasing ERa action (choice B) or amount (choice C) would suppress gonadotropins, countering its purpose. Decreasing gonadotropin secretion (choice D) is the opposite effect, as clomiphene boosts it. By disrupting estrogen's inhibitory signal, clomiphene mimics a low-estrogen state, prompting the pituitary to enhance ovulation. This mechanism distinguishes it from other fertility drugs, highlighting its role in anovulatory conditions like polycystic ovary syndrome, where precise hormonal manipulation is key to success.

Correct Answer: A

Rationale: Alendronate (choice A), a bisphosphonate, inhibits osteoclast activity, reducing bone resorption, increasing density in osteoporosis. It doesn't increase Ca2/Mg2 reabsorption (choice B), boost calcitriol (choice C), or alter phosphate reabsorption broadly (choice D). Osteoclast inhibition is its core action, vital for bone health.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.