ATI RN
ATI Pharmacology Proctored Exam Practice Questions Questions
Question 1 of 5
Which of the following agents if taken in overdose by a depressed patient is most likely to result in a fatal outcome?
Correct Answer: A
Rationale: Overdose fatality depends on toxicity and mechanism. Amitriptyline, a tricyclic antidepressant (TCA), blocks sodium channels and muscarinic receptors, causing lethal arrhythmias, seizures, and anticholinergic effects (LD50 ~13 mg/kg), making it highly fatal. Fluoxetine, fluvoxamine, paroxetine, and citalopram, all SSRIs, primarily cause serotonin syndrome or seizures, but lethality is lower (e.g., citalopram's QT risk is less immediate). TCAs' cardiotoxicity far exceeds SSRIs', driving amitriptyline's higher fatality rate, a critical factor in prescribing for depression with suicide risk.
Question 2 of 5
The goal of androgen therapy in men is to
Correct Answer: D
Rationale: Androgen therapy in men, typically testosterone replacement, aims to boost libido and treat erectile dysfunction by restoring normal androgen levels, countering hypogonadism's effects like reduced sexual drive. Decreasing libido contradicts its purpose, as low testosterone already dims desire. It doesn't release follicle-stimulating hormone (FSH)-exogenous androgens may suppress FSH and LH via feedback inhibition. Increasing luteinizing hormone (LH) isn't the goal; therapy bypasses LH by directly providing testosterone. Raising libido aligns with correcting symptoms of androgen deficiency, improving quality of life and sexual function, a primary clinical indication supported by its action on androgen receptors in sexual tissues.
Question 3 of 5
The patient receives a drug that is excreted in the bile. What will the best nursing assessment of the effect of this drug on the patient include?
Correct Answer: A
Rationale: Biliary excretion (e.g., rifampin) can prolong a drug's action via enterohepatic recycling-reabsorption from the gut extends duration, a key assessment point. Side effects don't inherently increase or decrease-dose and metabolism matter. Reduced effect assumes loss, not recycling. Prolonged action reflects pharmacokinetics, guiding monitoring for efficacy and toxicity.
Question 4 of 5
A patient presents with hypotension and bradycardia. The patient indicates that one of her physicians recently prescribed three new medications to her current list of 10 medications per day. Based on this information, which statement would be the most accurate?
Correct Answer: B
Rationale: Polypharmacy-13 drugs-raises interaction risks (e.g., beta-blockers plus CCBs causing hypotension/bradycardia), a common adverse outcome in complex regimens. Allergy lacks specific signs (e.g., rash). Non-compliance isn't indicated-she reports use. Transient effects need time evidence. Polypharmacy fits symptoms, per pharmacodynamics.
Question 5 of 5
The nurse assesses the client might be experiencing toxicity from colchicine. Which statement by the client would most likely confirm the nurse's suspicion?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.