Which of the following adverse effects is specific to the biguanide diabetic drug metformin

Correct Answer: C

Rationale: Lactic acidosis is an adverse effect specific to the biguanide diabetic drug metformin. It is a rare but serious complication associated with the use of metformin. Lactic acidosis occurs when there is a buildup of lactate in the body, leading to a decrease in pH levels. This condition can be life-threatening and requires immediate medical attention. Symptoms of lactic acidosis include rapid breathing, muscle pain or weakness, abdominal pain, dizziness, and irregular heartbeat. It is important for individuals taking metformin to be aware of the signs and symptoms of lactic acidosis and seek medical help if they experience them.

Correct Answer: C

Rationale: Valproate belongs to the category class of anticonvulsants, which means it is primarily used to treat seizures and epilepsy. Additionally, valproate also has properties that make it effective in the treatment of vascular headaches, such as migraines. It is not an anticoagulant, antianxiety medication like benzodiazepines, or a mood stabilizer.

Correct Answer: B

Rationale: Metformin (Glucophage) is a biguanide medication used to manage type 2 diabetes. While it is generally well-tolerated, one of its rare but serious adverse effects is lactic acidosis, a condition characterized by the buildup of lactic acid in the bloodstream. This can occur in patients with renal impairment or other risk factors. Hypoglycemia is uncommon with metformin alone, and GI distress, though common, is not life-threatening. Somnolence is not typically associated with metformin. Therefore, lactic acidosis is the most specific and serious adverse effect.

Correct Answer: D

Rationale: In the scenario described where the patient has accidentally taken too much warfarin (Coumadin) and is experiencing bleeding, the nurse can anticipate administering Vitamin K. Warfarin is an anticoagulant medication that works by inhibiting vitamin K-dependent clotting factors in the liver. By administering Vitamin K, it helps reverse the anticoagulant effect of warfarin by supplying the needed vitamin K for the production of clotting factors. This aids in the clotting process and helps to stop the bleeding that may occur due to excess warfarin in the system. Other medications listed (such as Protamine sulfate, Alteplase, Reteplase) are not specific antidotes for warfarin overdose-related bleeding but are used for different therapeutic purposes.

Correct Answer: B

Rationale: Protamine is the antidote for Heparin. Heparin is an anticoagulant medication that works by increasing the activity of antithrombin III, leading to the inhibition of clotting factors. In cases of excessive bleeding or overdose with Heparin, protamine can be administered to neutralize its anticoagulant effects. Protamine works by binding to heparin to form a stable complex, thereby reversing the anticoagulant activity of Heparin. It is important for healthcare providers to be familiar with the antidotes for various medications to manage potential complications effectively.