ATI RN
Pharmacology Assessment 1 ATI Capstone Questions
Question 1 of 5
Which drug combination is recommended for chronic hepatitis C infection?
Correct Answer: C
Rationale: Chronic hepatitis C (HCV) treatment targets viral clearance. Pegylated interferon alfa boosts immunity, lamivudine treats HBV, not HCV, so that's incorrect. Adefovir also targets HBV, not HCV. Pegylated interferon alfa with ribavirin, an antiviral, is a historical standard for HCV, enhancing sustained virologic response across genotypes, the recommended combo. Adefovir/lamivudine suits HBV, oseltamivir/zanamivir influenza. Ribavirin's synergy with interferon was key before direct-acting antivirals, effective for this condition.
Question 2 of 5
The drug that will most likely be used for treatment of erectile dysfunction (ED) is
Correct Answer: D
Rationale: Sildenafil (Viagra), a phosphodiesterase-5 inhibitor, treats erectile dysfunction (ED) by enhancing penile blood flow, a first-line therapy. Leuprolide suppresses testosterone for prostate cancer, worsening ED. Finasteride and tamsulosin, for BPH, don't target ED and may cause it. Sildenafil's vascular action offers rapid efficacy, making it the go-to choice.
Question 3 of 5
The patient and his wife receive the same medication for hypertension. The patient's wife asks the nurse why she is receiving a higher amount of the medication. What is the best response by the nurse?
Correct Answer: B
Rationale: Individual variation-metabolism, weight, genetics-dictates dose differences, a pharmacokinetic truth explaining her higher amount. Female metabolism isn't universally higher. Hormones affect response, but not broadly dose. Body fat impacts distribution, not directly dose here. Uniqueness covers all factors, reassuring and accurate.
Question 4 of 5
Benzodiazepines are often the drug of choice for managing anxiety and insomnia. Which statement best explains why?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
A 39-year-old man with chronic allergic rhinitis and nasal congestion takes an over-the-counter nasal spray containing oxymetazoline. Over the next few days, he has significant improvement in his symptoms. Which of the following is the most likely mechanism of action of this agent?
Correct Answer: C
Rationale: Oxymetazoline treats nasal congestion in allergic rhinitis by acting as an α-adrenergic agonist. Option , increased nasal blood flow, is incorrect-vasoconstriction reduces flow. Option , increased arterial pressure, doesn't directly relieve congestion. Option , receptor stimulation on nasal vasculature, is correct-oxymetazoline stimulates α-receptors, causing vasoconstriction, shrinking swollen mucosa, and improving airflow. Option , transmembrane conductance change, is unrelated to its action. Option (E), understimulation, contradicts its agonist role. This vasoconstrictive effect rapidly alleviates congestion, explaining the symptom improvement. Unlike antihistamines or steroids, oxymetazoline targets vascular tone, not inflammation or histamine, making it ideal for quick relief in rhinitis. Prolonged use risks rebound congestion, but the question focuses on initial efficacy, where receptor-mediated vasoconstriction is key.