ATI RN
Intro to Pharmacology ATI Questions
Question 1 of 9
Which combination of local anesthesia produces EMLA ( Eutectic Mixture of Local Anesthetics):
Correct Answer: B
Rationale: EMLA (Eutectic Mixture of Local Anesthetics) is a commonly used topical local anesthetic cream. It contains a combination of lidocaine and prilocaine. This combination of local anesthetics work together to provide effective pain relief when applied to the skin before certain medical procedures like needle insertion, laser treatment, or minor skin surgeries. Lidocaine and prilocaine work by blocking nerve signals in the skin, reducing sensations of pain and discomfort in the area where the cream is applied.
Question 2 of 9
Combination chemotherapy is used in the treatment of cancer because:
Correct Answer: A
Rationale: Combination chemotherapy is used to target cancer cells through multiple mechanisms, reducing the likelihood of resistance. Single-agent therapy often leads to the development of resistant cell lines, as cancer cells can adapt to the drug. By using a combination of drugs with different mechanisms of action, the treatment can more effectively kill cancer cells and prevent resistance. While two drugs may increase efficacy, the primary rationale is to overcome resistance. Larger doses of single agents are not the main reason for combination therapy.
Question 3 of 9
Which combination of local anesthesia produces EMLA ( Eutectic Mixture of Local Anesthetics):
Correct Answer: B
Rationale: EMLA (Eutectic Mixture of Local Anesthetics) is a commonly used topical local anesthetic cream. It contains a combination of lidocaine and prilocaine. This combination of local anesthetics work together to provide effective pain relief when applied to the skin before certain medical procedures like needle insertion, laser treatment, or minor skin surgeries. Lidocaine and prilocaine work by blocking nerve signals in the skin, reducing sensations of pain and discomfort in the area where the cream is applied.
Question 4 of 9
A 52-year-old man with asthma treated with a β2 agonist via inhaler has been having difficulty with therapy because of persistent changes in blood pressure, nausea, vomiting, and hypomagnesemia. Which of the following medications would be best for this patient?
Correct Answer: D
Rationale: β2-agonist side effects (BP changes, nausea, hypomagnesemia) suggest overuse. Ipratropium , an anticholinergic bronchodilator, avoids these. Options , , persist with β2-agonists, risking side effects. Epinephrine (E) worsens them. Ipratropium's different mechanism improves asthma control safely.
Question 5 of 9
An otherwise healthy 78-year-old man is found to have a blood pressure (BP) of 168/80 at a routine check, and similar pressures are confirmed on three separate occasions despite adhering to dietary advice. Investigations including an ECG and creatinine/electrolytes are normal. Which of the following is the most appropriate next step in management?
Correct Answer: D
Rationale: Systolic hypertension (168 mmHg) in the elderly increases cardiovascular risk, despite normal diastolic (80 mmHg). Echo isn't first-line without organ damage signs (normal ECG). Reassurance ignores systolic risk; treatment is indicated (>160 mmHg). Doxazosin, an alpha-blocker, is less preferred initially due to hypotension risk. Ramipril, an ACE inhibitor, is effective, but amlodipine, a calcium channel blocker, is most appropriate per guidelines (e.g., NICE) for isolated systolic hypertension in the elderly, offering vascular protection and tolerability. Its efficacy reduces stroke and MI risk, critical at this age.
Question 6 of 9
A 36-year-old man is brought to the emergency department after being involved in a one-car motor vehicle accident where his car struck a telephone pole. He is a known chronic alcoholic. He smells alcohol on his breath, and his blood alcohol level is 300 mg/dL. Which of the following treatments should be given to him if he goes into alcohol withdrawal?
Correct Answer: B
Rationale: Alcohol withdrawal in a chronic alcoholic (300 mg/dL) requires lorazepam . This benzodiazepine mimics alcohol's GABA enhancement, preventing seizures and agitation. Buspirone treats anxiety, not withdrawal. Pentobarbital is excessive. Phenytoin targets seizures alone. Saline (E) supports but doesn't treat. Lorazepam's safety is key.
Question 7 of 9
The client receives nystatin (Nilstat) for a fungal infection in the mouth. The nurse plans to do medication education prior to discharge. What will the best plan by the nurse include?
Correct Answer: A
Rationale: Nystatin is an antifungal used for oral candidiasis (thrush), and its effectiveness depends on proper administration. For oral infections, the medication must remain in contact with the affected mucosal surfaces as long as possible. Dissolving the tablet in the mouth ensures prolonged exposure to the fungus, allowing it to act locally before swallowing, which is the recommended method for tablets or lozenges. Using a straw might apply to suspensions but isn't standard for preventing discoloration, which isn't a primary concern with nystatin. Crushing and mixing with juice alters the drug's intended delivery, reducing contact time with the infection site. Swallowing whole bypasses the oral mucosa entirely, rendering it ineffective for thrush. Thus, choice A aligns with nystatin's mechanism, ensuring optimal therapeutic outcomes through direct mucosal contact.
Question 8 of 9
Which of the following are possible mechanisms for the bactericidal/bacteriostatic effects of antiseptics and disinfectants?
Correct Answer: A
Rationale: Antiseptics and disinfectants exert their bactericidal/bacteriostatic effects through various mechanisms, including:
Question 9 of 9
The physician orders penicillin for a female client who has a sinus infection. What is a priority question to ask the client prior to administering the medication?
Correct Answer: A
Rationale: Penicillin, a beta-lactam antibiotic, is generally safe (Category B) but requires pregnancy status clarification before administration. Pregnancy alters drug metabolism and dosing, and while penicillin poses minimal fetal risk, confirming status ensures no hypersensitivity or rare contraindications are overlooked, prioritizing maternal and fetal safety. Future pregnancy plans are less immediate, affecting long-term considerations, not current use. Breastfeeding matters due to minimal excretion in milk, but it's secondary to current pregnancy. Birth control interaction is negligible with penicillin, unlike other antibiotics. Asking 'Are you pregnant?' addresses the most urgent safety concern, aligning with nursing's role in preventing adverse outcomes, making A the priority question before initiating therapy.