Correct Answer: A

Rationale: The correct answer is A: Streptococcus pneumoniae. This bacterium is the most common cause of bacterial pneumonia in adults. It is a leading cause of community-acquired pneumonia. Streptococcus pneumoniae is known for its ability to infect the respiratory tract and cause inflammation in the lungs leading to pneumonia. Mycobacterium tuberculosis causes tuberculosis, not pneumonia. Escherichia coli is associated with urinary tract infections and gastrointestinal illnesses, not pneumonia. Clostridium botulinum causes botulism, a severe form of food poisoning, but not pneumonia. Therefore, the correct choice is Streptococcus pneumoniae as it is specifically known for causing pneumonia.

Correct Answer: A

Rationale: The correct answer is A: Isoniazid. When rifampicin is used alone, there is a risk of developing resistance. Isoniazid is commonly used in combination with rifampicin to prevent resistance by targeting different mechanisms in the bacteria. Isoniazid works by inhibiting mycolic acid synthesis, while rifampicin targets RNA polymerase. This combination therapy is known as the first-line treatment for tuberculosis. Choices B, C, and D are incorrect because they do not have the same mechanism of action as isoniazid and would not be effective in preventing rifampicin resistance.

Correct Answer: B

Rationale: B cells develop in the bone marrow, not the thymus. Firstly, hematopoietic stem cells in the bone marrow give rise to B cells. They undergo maturation and selection processes in the bone marrow, not in the thymus. Therefore, choice B is false. On the other hand, choices A, C, and D are correct. A is true because B cells with high affinity to self-antigens undergo apoptosis to prevent autoimmunity. C is true since B cells synthesize antibodies which can be displayed on their surface as B cell receptors. D is true because B cells can undergo class switching to produce different types of antibodies based on the immune response requirements.

Correct Answer: D

Rationale: Step-by-step rationale: 1. The study results indicate water contamination. 2. Contaminated water poses health risks. 3. Therefore, the correct interpretation is that water is contaminated. Summary: - Choice A is incorrect as safety is not confirmed. - Choice B is too mild given the severity of contamination. - Choice C is also incorrect, as it does not accurately reflect the study findings.

Correct Answer: B

Rationale: The correct answer is B: Typhoid fever. Typhoid fever is transmitted through the fecal-oral route, meaning the bacteria from an infected person's feces can contaminate food or water and then be ingested by another person. This can lead to infection and illness. The other choices, diphtheria (A), syphilis (C), and spotted fever (D) are not transmitted through the fecal-oral route. Diphtheria is spread through respiratory droplets, syphilis is primarily sexually transmitted, and spotted fever is transmitted through tick bites. Thus, only Typhoid fever aligns with the fecal-oral route of transmission.