ATI RN
ATI Pharmacology Practice Exam B Questions
Question 1 of 5
Which action is most important for the nurse to teach a patient who is taking tositumomab?
Correct Answer: C
Rationale: Tositumomab is a radioactive monoclonal antibody used in cancer treatment. Patients should be advised to use a separate bathroom and sit while urinating to minimize radiation exposure to others and themselves. This precaution is necessary because the drug is excreted in urine, which remains radioactive for a period after treatment. Avoiding alcohol or smoking is not specifically related to tositumomab therapy. Taking the drug on an empty stomach is not applicable, as it is administered intravenously.
Question 2 of 5
The nurse is reviewing new medication orders that have been written for a newly admitted patient. The nurse will need to clarify which orders? Select all that apply.
Correct Answer: D
Rationale: Medication orders must be clear, complete, and appropriate for the patient's condition. Orders that include 'as needed' (PRN) medications, such as 'Docusate (Colace) as needed for constipation,' require clarification because they lack specific dosing instructions. The nurse must confirm the frequency, dosage, and indications for PRN medications to ensure safe administration. The other orders (Metformin, Sitagliptin, Simvastatin, and Irbesartan) are complete and do not require clarification. Therefore, the nurse should focus on clarifying the PRN order to avoid errors in medication administration.
Question 3 of 5
Chris asks the nurse whether all donor blood products are cross-matched with the recipient to prevent a transfusion reaction. Which of the following always require cross-matching?
Correct Answer: D
Rationale: Packed red blood cells (PRBCs) always require cross-matching to ensure compatibility between the donor and recipient blood types. Cross-matching involves testing the recipient's serum against the donor's red cells to detect antibodies that could cause a transfusion reaction. Granulocytes, platelets, and plasma do not require cross-matching in the same way, although they may undergo other compatibility tests. PRBCs are the most critical to match correctly due to the risk of hemolytic reactions, which can be life-threatening.
Question 4 of 5
It is rational and advised therapeutic practice to commence treatment with the following drug using a loading dose if a rapid onset of action is required:
Correct Answer: C
Rationale: A loading dose achieves therapeutic levels quickly for drugs with long half-lives or urgent needs. Clozapine's slow titration avoids agranulocytosis, not rapid loading. Zolmitriptan, for acute migraine, acts fast without loading due to short half-life. Amiodarone, with a half-life of weeks, uses loading doses (e.g., 800-1600 mg/day) to rapidly control arrhythmias, rational for urgent onset. Levodopa's short half-life and titration in Parkinson's don't require loading. Doxazosin, for hypertension, starts low to avoid first-dose hypotension. Amiodarone's pharmacokinetics and arrhythmia urgency make loading advised, balancing efficacy and toxicity risks.
Question 5 of 5
Regarding diazepam:
Correct Answer: B
Rationale: Diazepam, a benzodiazepine, has active metabolites (e.g., desmethyldiazepam) with longer half-lives, contributing to its effects, so that's false. Activated charcoal is effective in overdose by adsorbing diazepam, reducing absorption, a true statement and standard intervention. It undergoes minimal, not extensive, enterohepatic recirculation, making that false. It's a GABA agonist, enhancing chloride influx via benzodiazepine receptors, not an antagonist, so that's incorrect. It also inhibits spinal reflexes, aiding muscle relaxation. The overdose utility of charcoal highlights its role in emergency management, binding unabsorbed drug in the gut, a key pharmacokinetic intervention distinct from flumazenil reversal.