When used alone, the bile acid-binding resins are contraindicated in patients with hypertriglyceridemia. This consideration is:

Correct Answer: A

Rationale: The correct answer is A: TRUE. Bile acid-binding resins can worsen hypertriglyceridemia by increasing triglyceride levels. This is due to the compensatory increase in hepatic triglyceride synthesis. Choice B is incorrect because it contradicts this established fact. Choice C is incorrect as it implies all options are true, which is not the case. Choice D is incorrect as it suggests that none of the options are true, which is also not accurate.

Correct Answer: D

Rationale: The correct answer is D: Spironolactone (Aldactone). Spironolactone has a steroid-like structure due to its chemical similarity to aldosterone, allowing it to competitively inhibit aldosterone receptors. This anti-androgenic effect is crucial in conditions like hirsutism and acne. Amiloride (A), Furosemide (B), and Hydrochlorothiazide (C) do not possess a steroid-like structure and do not exhibit anti-androgenic properties.

Correct Answer: A

Rationale: The correct answer is A: Doxycycline, as it belongs to the tetracycline class of antibiotics. Tetracyclines inhibit bacterial protein synthesis by binding to the bacterial ribosome. Streptomycin (B) is an aminoglycoside, Clarithromycin (C) is a macrolide, and Amoxicillin (D) is a penicillin; these do not belong to the tetracycline class.

Correct Answer: B

Rationale: The correct answer is B because isoniazid inhibits the synthesis of mycolic acids, a crucial component of the cell wall of Mycobacterium tuberculosis. By blocking mycolic acid synthesis, isoniazid disrupts the integrity of the bacterial cell wall, leading to cell death. Choices A, C, and D are incorrect because isoniazid does not affect protein synthesis, RNA synthesis, or ADP synthesis. These processes are not targeted by isoniazid in its mechanism of action against tuberculosis.

Correct Answer: D

Rationale: Step-by-step rationale for choosing Pyrantel for nematodosis treatment: 1. Pyrantel is a well-known anthelmintic drug effective against roundworms. 2. It works by causing paralysis in the worms, leading to their expulsion from the body. 3. Pyrantel is commonly used to treat various nematode infections in humans. 4. Niclosamide is more effective against tapeworms, not nematodes. 5. Praziquantel is used for tapeworm and fluke infections, not specifically for nematodes. 6. Bithionol is an older drug with limited use and not commonly used for nematodosis treatment.