When the nurse is administering topical nitroglycerin ointment, which technique is correct?

Correct Answer: D

Rationale: The correct technique when administering topical nitroglycerin ointment is to remove the old ointment before applying the new ointment. This is to prevent any potential overdosing of the medication, as nitroglycerin can be rapidly absorbed through the skin. It is important to ensure that the previous application is fully removed before applying a new dose to prevent any accumulation of the medication.

Correct Answer: A

Rationale: Patients with peptic ulcers should stop taking NSAIDs. NSAIDs, which stands for nonsteroidal anti-inflammatory drugs, can worsen peptic ulcers by increasing the risk of gastrointestinal bleeding and ulcer formation. NSAIDs work by inhibiting prostaglandin synthesis, which can lead to a decrease in the protective mucus production in the stomach lining, allowing gastric acid to damage the mucosa and exacerbate peptic ulcers. Therefore, it is crucial for patients with peptic ulcers to avoid NSAIDs to prevent further damage to the gastrointestinal tract.

Correct Answer: A

Rationale: Penicillin G is a beta-lactam antibiotic that can cause severe allergic reactions, including anaphylaxis. Having epinephrine on hand is crucial for managing such emergencies. Collecting a culture and sensitivity before the first dose ensures the infection is caused by a penicillin-susceptible organism. Mouth ulcers are not a common side effect of penicillin, but monitoring for superinfections like oral thrush is important. Limiting fluid intake to 1000 mL/day is incorrect, as adequate hydration helps maintain renal function and prevents crystalluria. No particular interventions are required is incorrect, as penicillin requires careful monitoring for efficacy and adverse effects.

Correct Answer: A

Rationale: Acetaminophen overdose initially presents asymptomatically, but its toxic metabolite, NAPQI, causes delayed harm. Option , depletion of endogenous antioxidants (glutathione), is correct-NAPQI, formed via CYP450 metabolism, overwhelms glutathione, leading to oxidative stress and hepatotoxicity. Option , hapten formation, occurs with some drugs but not acetaminophen's primary toxicity. Option , cytochrome C oxidase inhibition, is cyanide's mechanism, not acetaminophen's. Option , ischemia from reduced blood flow, isn't the issue-damage is metabolic. Option (E), gallbladder paralysis, is irrelevant. NAPQI's glutathione depletion disrupts detoxification, causing centrilobular necrosis, explaining the delayed presentation and justifying urgent treatment like N-acetylcysteine to replenish glutathione.

Correct Answer: A

Rationale: Tetracycline causes tooth discoloration by binding to calcium in developing teeth . Drug toxicity is vague. Folate synthesis , hepatic enzymes , and osteoclasts (E) aren't involved. This chelation stains enamel, a known effect with prolonged use.