ATI RN
ATI Pharmacology Study Guide Questions
Question 1 of 5
When teaching a patient who is beginning antilipemic therapy about possible drug-food interactions, the nurse will discuss which food?
Correct Answer: B
Rationale: The nurse will discuss grapefruit juice when teaching a patient about possible drug-food interactions with antilipemic therapy. Grapefruit juice can inhibit the enzyme CYP3A4 in the liver, which can affect the metabolism of certain medications, including some antilipemic drugs. This interaction may lead to increased drug levels in the bloodstream, potentially causing harmful side effects. It is important for patients to be aware of this interaction and to consult their healthcare provider if they consume grapefruit juice while on antilipemic therapy.
Question 2 of 5
Action of antiemetic drugs
Correct Answer: D
Rationale: Antiemetic drugs are medications used to prevent and treat nausea and vomiting. Therefore, the main action of antiemetic drugs is to prevent vomiting, making option E the correct answer. Antiemetic drugs work by reducing or blocking the signals to the vomiting center in the brain, thus helping to alleviate the symptoms of nausea and prevent vomiting.
Question 3 of 5
What is the classification for the drug valproate?
Correct Answer: B
Rationale: Valproate is classified as an anti-convulsant medication. It is commonly used to treat seizures, particularly in the management of epilepsy. Valproate works by affecting certain chemicals in the brain to control seizures and stabilize mood in some psychiatric conditions. It is not classified as an anti-diabetic, anti-ulcer agent, or anti-hypertensive medication.
Question 4 of 5
Midazolam is an effective anesthetic because it acts by
Correct Answer: D
Rationale: Midazolam is a short-acting benzodiazepine widely used as an anesthetic due to its rapid onset and potent sedative effects. Its mechanism involves enhancing the activity of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, at GABA_A receptors—not GABA_B receptors, which are linked to different effects like muscle relaxation. By binding to a specific site on the GABA_A receptor, midazolam increases the frequency of chloride channel opening, leading to greater chloride ion conductance into neurons. This hyperpolarizes the neuron, making it less excitable and producing sedation, anxiolysis, and anesthesia. Dopamine enhancement is unrelated to its action, as is NMDA receptor blockade, which is a feature of drugs like ketamine. Partial agonism at serotonin (5HT) receptors also does not apply here. The facilitation of GABA-mediated chloride conductance is the precise mechanism that underpins midazolam's clinical utility as an anesthetic agent.
Question 5 of 5
The nurse is preparing to administer an injection to a preschool-age child. Which approaches are appropriate for this age group? (Select all that apply.)
Correct Answer: D
Rationale: Preschool-age children benefit from brief, concrete explanations about medical procedures, as they have limited understanding of abstract concepts. Encouraging participation, such as allowing the child to choose a bandage or hold a toy, can reduce anxiety and increase cooperation. Providing comfort measures, such as praise or a small reward, after the injection helps reinforce positive behavior. While magical thinking is characteristic of this age group, it is not an appropriate strategy for explaining medical procedures. Therefore, the nurse should focus on concrete explanations, participation, and comfort measures.