When taking Nitroglycerine (transdermal), you should have how many hours nitrate free each day?

Correct Answer: C

Rationale: When taking Nitroglycerine (transdermal), it is recommended to have a nitrate-free interval of at least 10-12 hours to prevent tolerance from developing. Tolerance can occur if the medication is continuously delivered without a break, leading to reduced effectiveness. Therefore, having a nitrate-free interval of 3-4 hours each day helps to maintain the efficacy of Nitroglycerine therapy and prevent tolerance.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Amlodipine is a medication that is taken orally, usually in the form of tablets. The abbreviation "PO" stands for per os, which means by mouth or orally. Amlodipine is widely prescribed to treat high blood pressure and certain types of chest pain. It works by relaxing the blood vessels, making it easier for the heart to pump blood. Taking amlodipine orally allows it to be absorbed through the digestive system and enter the bloodstream to exert its therapeutic effects.

Correct Answer: C

Rationale: Antacids or antidiarrheals should be avoided for at least 4 hours after taking digoxin. These medications can interfere with the absorption of digoxin in the body, thereby reducing its effectiveness. By spacing out the administration of these medications, the risk of decreased digoxin absorption and potential impact on its therapeutic effects can be minimized. It is important for patients to follow this guidance to ensure optimal effectiveness of digoxin therapy.

Correct Answer: D

Rationale: The placenta is not a site for drug metabolism. Drug metabolism primarily occurs in the liver, gastrointestinal tract (GIT), skin, and kidney. The placenta serves as a barrier between the mother and fetus and is involved in nutrient and waste exchange but does not play a significant role in drug metabolism processes.