What type of study design is best suited for studying the natural history of a disease?

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Question 1 of 5

What type of study design is best suited for studying the natural history of a disease?

Correct Answer: C

Rationale: Cohort studies (C) follow disease progression over time (e.g., HIV stages). A is snapshot, B is retrospective, D is interventional.

Question 2 of 5

What type of bias occurs when the measurement of exposure or outcome is influenced by the knowledge of the hypothesis?

Correct Answer: D

Rationale: Observer bias (D) arises when hypothesis knowledge skews measurement (e.g., biased scoring). A is selection, B is broad, C is recall-specific.

Question 3 of 5

Which of the following is an example of selection bias?

Correct Answer: A

Rationale: Loss to follow-up (A) is selection bias if related to exposure-outcome (e.g., sicker patients leaving). B, C, and D are information biases.

Question 4 of 5

Specificity of a diagnostic test is defined as:

Correct Answer: B

Rationale: Specificity (B) is true negatives / (true negatives + false positives), ruling out non-diseased (e.g., 95% specificity = 95% healthy identified). A is sensitivity, C is NPV, D is an error.

Question 5 of 5

What does a likelihood ratio of less than 1 indicate?

Correct Answer: B

Rationale: LR < 1 (B) means a result favors non-disease (e.g., LR- = (1-sensitivity) / specificity). A, C, and D misinterpret.

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