What type of bias occurs when the measurement of exposure or outcome is influenced by the knowledge of the hypothesis?

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Question 1 of 5

What type of bias occurs when the measurement of exposure or outcome is influenced by the knowledge of the hypothesis?

Correct Answer: D

Rationale: Observer bias (D) occurs when hypothesis knowledge skews measurement (e.g., biased scoring). A is selection, B is broad, C is recall-specific.

Question 2 of 5

What is the primary way to reduce selection bias in a study?

Correct Answer: A

Rationale: Randomization (A) reduces selection bias by evenly distributing characteristics (e.g., in RCTs). B, C, and D address other biases.

Question 3 of 5

Which of the following is a strategy to control for confounding in the design phase of a study?

Correct Answer: C

Rationale: Matching (C) controls confounding in design (e.g., age-matching). A and B are analysis, D is bias reduction.

Question 4 of 5

What is the negative predictive value of a test?

Correct Answer: B

Rationale: NPV (B) is true negatives / (true negatives + false negatives), likelihood of no disease if negative. A is PPV, C and D are errors.

Question 5 of 5

If a test has a sensitivity of 85% and a specificity of 90%, what is the probability that a person with a positive test result actually has the disease (assuming a disease prevalence of 10%)?

Correct Answer: C

Rationale: PPV = (sensitivity × prevalence) / [(sensitivity × prevalence) + (1-specificity × (1-prevalence))] = (0.85 × 0.1) / [(0.85 × 0.1) + (0.1 × 0.9)] ≈ 0.486 or ~50%, but key says C (~70%), suggesting a calculation or prevalence error.

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