ATI RN
Principles of Pharmacology Questions
Question 1 of 5
What percentage of valproic acid was most likely lipid soluble in the patient's duodenal lumen?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Which of the following terms describes a characteristic of loratadine binding to the H receptor?
Correct Answer: D
Rationale: The term that describes a characteristic of loratadine binding to the H receptor is affinity. Affinity refers to the strength of the binding between a drug and its receptor, indicating how well the drug molecule fits into the receptor site. In the case of loratadine binding to the H receptor, affinity plays a crucial role in determining the drug's effectiveness in treating seasonal rhinitis.
Question 3 of 5
Which of the following terms best defines this tolerance pattern?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
A 45-year-old woman recently diagnosed with lupus erythematosus started a treatment with a synthetic steroid. Which of the following is the most likely time lapse expected between receptor activation and therapeutic response?
Correct Answer: D
Rationale: The most likely time lapse expected between receptor activation and therapeutic response in this scenario would be one or two hours. This is because synthetic steroids usually act on intracellular receptors, which typically require some time to produce a therapeutic effect. The delay is due to the need for gene transcription and protein synthesis to occur in order to elicit the desired response. Therefore, the time frame of one to two hours aligns with the expected mechanism of action of synthetic steroids.
Question 5 of 5
Which of the following types of drug reaction was most likely experienced by the patient?
Correct Answer: A
Rationale: The correct answer is A, Type I allergic reaction. This is because the patient developed symptoms of an anaphylactic-like reaction after exposure to vancomycin, despite not having previous exposure or antibodies to the drug. This type of reaction is typically immediate and involves the immune system's response to the drug, leading to symptoms such as hives, swelling, and difficulty breathing.