ATI RN
Principles of Pharmacology Quizlet Questions
Question 1 of 5
What percentage of the drug was most likely lipid soluble in the patient's duodenal lumen?
Correct Answer: B
Rationale: Lipid solubility of a drug is influenced by its pKa value. Since valproic acid has a pKa of 5, it would likely be lipid soluble at a pH of 7 in the duodenal lumen. The Henderson-Hasselbalch equation suggests that when the pH is higher than the pKa, the drug will predominantly be in its non-ionized, lipid-soluble form. In this case, the drug would be about 24% lipid soluble in the duodenal lumen, making choice B the correct answer.
Question 2 of 5
Which of the following pairs of drugs can fully activate the same receptors?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 3 retries using GPT-3.5.
Question 3 of 5
The figure below depicts the in vitro log dose-response curves of different drugs acting on the same receptor. Drug Z was able to antagonize the effects of both drug X and drug Y. Which of the following terms best defines drug X?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 3 retries using GPT-3.5.
Question 4 of 5
What percentage of atenolol would be bound if a dose of 50 mg/d was administered to the patient?
Correct Answer: B
Rationale: The correct answer is B (5%) because the question is asking for the bound percentage of atenolol after a specific dose has been administered. Since the dose is 50 mg/d, the correct answer can be calculated as 50 mg/d / 1000 mg/g x 0.10 (10%) = 5%. This calculation shows that 5% of the atenolol would be bound.
Question 5 of 5
Which of the following was the most likely cause of the patient's disorder?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 3 retries using GPT-3.5.