ATI RN
Pharmacology Assessment 1 ATI Capstone Questions
Question 1 of 5
What is the unlabeled use for
Correct Answer: A
Rationale: The unlabeled use for a medication refers to a use that is not approved by regulatory agencies but has shown effectiveness in clinical practice. In this case, the unlabeled use for a medication might be to treat PTSD (Post-Traumatic Stress Disorder). While the medication may not be specifically indicated for this condition, it may have shown benefits in managing the symptoms of PTSD based on clinical experience or research studies. It is important to note that using a medication for an unlabeled use should always be done under the supervision of a healthcare professional.
Question 2 of 5
A patient with , should stop taking NSAIDS
Correct Answer: A
Rationale: Patients with peptic ulcers should stop taking NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) because NSAIDs can worsen the condition and increase the risk of gastrointestinal bleeding and ulcer perforation. NSAIDs inhibit prostaglandin synthesis, which normally helps protect the stomach lining. Therefore, patients with peptic ulcers should avoid NSAIDs and consult their healthcare provider for alternative pain management options.
Question 3 of 5
A 29-year-old male patient is being treated with an antidepressant drug, and his mood is improving. However, he complains of feeling 'jittery' and agitated at times, and if he takes his medication in the afternoon he finds it difficult to get to sleep at night. He seems to have lost weight during the 6 months that he has been taking the drug. He has been warned not to take other drugs without consultation because severe reactions have occurred with opioid analgesics including meperidine. This patient is probably taking
Correct Answer: C
Rationale: Paroxetine, an SSRI, treats depression by inhibiting serotonin reuptake, often improving mood. Its side effects include agitation and insomnia (especially if taken late), due to serotonin's stimulating effects, and weight loss can occur initially, unlike TCAs which cause gain. A critical clue is the warning against opioids like meperidine: SSRIs can cause serotonin syndrome when combined with MAOIs or other serotonergic drugs, though meperidine's risk is notable in polypharmacy. Alprazolam, a benzodiazepine, sedates rather than agitates. Chlorpromazine, an antipsychotic, causes sedation and weight gain. Amitriptyline, a TCA, is sedating and linked to weight gain, not loss. Trazodone promotes sleep. Paroxetine's profile—activation, insomnia, weight loss, and drug interaction risks—matches the patient's experience.
Question 4 of 5
The following inhibit at least one of the hepatic CYP450 isoenzymes:
Correct Answer: B
Rationale: Grapefruit juice inhibits CYP3A enzymes, affecting the metabolism of several drugs and potentially leading to increased plasma concentrations.
Question 5 of 5
A client with hypertension is prescribed lisinopril (Prinivil). Which statement by the client indicates a need for further teaching?
Correct Answer: C
Rationale: Lisinopril, an ACE inhibitor, manages hypertension but requires adherence even if symptoms improve, as stopping abruptly risks rebound hypertension, indicating a teaching gap. Reporting a dry cough is correct due to bradykinin buildup, a common side effect needing evaluation. Rising slowly prevents orthostatic hypotension, a known effect. Avoiding potassium-rich salt substitutes prevents hyperkalemia, as lisinopril inhibits aldosterone. The statement ‘I can stop this medication if I feel better' reflects misunderstanding of chronic disease management, where consistent therapy maintains control, not just symptom relief. Further teaching must emphasize this, aligning with lisinopril's role in long-term vascular protection, making C the statement needing correction.