ATI RN
How to Study for ATI Pharmacology Proctored Exam Questions
Question 1 of 5
What is the therapeutic classification of Omeprazole?
Correct Answer: B
Rationale: Omeprazole is classified as an antiulcer agent. It belongs to the class of medications known as proton pump inhibitors (PPIs), which work by reducing the production of stomach acid. Omeprazole is commonly used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. Its main therapeutic effects include reducing stomach acid secretion and promoting the healing of ulcers.
Question 2 of 5
The metabolism of the drug en route from the gut lumen to the systemic circulation.
Correct Answer: B
Rationale: The first pass effect refers to the metabolism of a drug as it passes through the liver before reaching the systemic circulation. When a drug is absorbed from the gut lumen, it first enters the portal circulation where it is transported to the liver. In the liver, the drug may undergo metabolic processes that can reduce the amount of active drug reaching systemic circulation. This process can greatly affect the overall bioavailability and effectiveness of the drug. So, the metabolism of the drug en route from the gut lumen to the systemic circulation is primarily due to the first pass effect.
Question 3 of 5
Which patient is the best candidate to receive nesiritide therapy?
Correct Answer: D
Rationale: Nesiritide is a recombinant form of human B-type natriuretic peptide (BNP) that is used for the treatment of acutely decompensated heart failure (HF). It is specifically indicated for patients with acute decompensated HF who have dyspnea at rest. Nesiritide works by promoting vasodilation and natriuresis, which helps alleviate symptoms of acute decompensated HF such as dyspnea and edema. Therefore, the patient with acutely decompensated HF who has dyspnea at rest is the best candidate to receive nesiritide therapy to help improve their symptoms and hemodynamic status.
Question 4 of 5
A patient has a digoxin level of 1.1 ng/mL. Which interpretation by the nurse is correct?
Correct Answer: B
Rationale: The therapeutic range for digoxin levels is typically considered to be between 0.5 to 2.0 ng/mL for patients with heart failure. A digoxin level of 1.1 ng/mL falls within this range, indicating that the patient's digoxin level is appropriate for therapeutic effects. This level suggests that the patient is receiving an appropriate dose of digoxin to achieve the desired therapeutic response without reaching toxic levels.
Question 5 of 5
Which drug goes through extensive first-pass hepatic metabolism?
Correct Answer: C
Rationale: Propranolol goes through extensive first-pass hepatic metabolism. This means that after oral administration, a significant portion of the drug is metabolized by the liver before it reaches systemic circulation. This process reduces the bioavailability of propranolol. As a result, higher doses are often required for oral administration compared to other routes of administration, such as intravenous. Heparin, insulin, nitroglycerine, and warfarin do not undergo extensive first-pass metabolism in the liver.