What is the purpose of autophagy in the presentati

Question 1 of 5

What is the purpose of autophagy in the presentation of self peptides by MHC II molecules in the thymus?

A. To allow T cells to recognize foreign antigens B. To allow T cells to recognize tissue-specific antigens C. To allow MHC II molecules to capture and present intracellular proteins D. To allow MHC I molecules to capture and present intracellular proteins

Correct Answer: C

Rationale: Autophagy enables MHC II to present intracellular self-peptides ; not foreign , tissue-specific is broader, MHC I uses TAP.

Question 2 of 5

Several subsets of innate lymphoid cells (ILCs) have been identified that share their patterns of cytokine production with the known subsets of T cells. The combined activity of related ILC and T cell subsets is effective in eradicating pathogenic infections because:

A. ILCs cannot kill the pathogen, whereas the antigen-specific T cells can kill the pathogen B. The early response of ILCs that reside at the site of infection is followed by the later more robust response of pathogen-specific T cells that migrate to the site of infection C. The ILCs activate B cells to induce antibody responses whereas the T cells are able to directly eliminate the pathogen D. The ILCs are induced to migrate from the site of infection to the draining lymph nodes where they activate the antigen-specific T cells

Correct Answer: B

Rationale: ILCs respond early, followed by specific T cells ; ILCs aid killing , don't solely activate B cells , or migrate to nodes .

Question 3 of 5

Septic shock is a serious, often fatal response to an infection in the bloodstream. This response can be elicited in mice by intravenous injection of bacterial LPS. However, it was found that one strain of mice, C3H/HeJ, is resistant to LPS-induced shock. This fact was used to clone the gene for TLR-4 based on positional cloning from C3H/HeJ mice. Another example of a strain of mice that is resistant to LPS-induced septic shock is:

A. TNF-receptor-deficient mice B. TLR-2-deficient mice C. LFA-1-deficient mice D. Neutrophil-deficient mice

Correct Answer: A

Rationale: TNF-receptor-deficient mice resist LPS shock as TNF drives inflammation; TLR-2 targets other PAMPs, LFA-1 or neutrophils are secondary.

Question 4 of 5

The experiment shown in Figure Q6.19 uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. The explanation for the results of this experiment is:

A. Mice of strain B do not make a T cell response to LCMV B. Mice of strain A make a more robust T cell response to LCMV than mice of strain B C. Target cells that express H-2^b cannot be infected with LCMV D. T cells from mice of strain A only recognize viral peptides on target cells expressing H-2^a

Correct Answer: D

Rationale: T cells are MHC-restricted; strain A T cells recognize H-2^a ; both strains respond (A, B), H-2^b cells are infected .

Question 5 of 5

The body's innate defenses against infection include

A. several nonspecific antibodies B. barriers such as dead skin cells and mucus C. increased production of certain hormones and changes in microcirculation D. memory cells

Correct Answer: B

Rationale: Innate defenses are nonspecific and include physical barriers like dead skin cells and mucus, which prevent pathogen entry, unlike antibodies or memory cells (adaptive immunity).

What is the purpose of autophagy in the presentation of self peptides by MHC II molecules in the thymus?

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