What is the primary way to reduce selection bias in a study?

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130 Top Epidemiology Multiple Choice Questions and Answers PDF Questions

Question 1 of 5

What is the primary way to reduce selection bias in a study?

Correct Answer: A

Rationale: Randomization (A) reduces selection bias by evenly distributing characteristics (e.g., in RCTs). B, C, and D address other biases.

Question 2 of 5

What is the negative predictive value of a test?

Correct Answer: B

Rationale: NPV (B) is true negatives / (true negatives + false negatives), likelihood of no disease if negative. A is PPV, C and D are errors.

Question 3 of 5

If a test has a sensitivity of 85% and a specificity of 90%, what is the probability that a person with a positive test result actually has the disease (assuming a disease prevalence of 10%)?

Correct Answer: C

Rationale: PPV = (sensitivity × prevalence) / [(sensitivity × prevalence) + (1-specificity × (1-prevalence))] = (0.85 × 0.1) / [(0.85 × 0.1) + (0.1 × 0.9)] ≈ 0.486 or ~50%, but key says C (~70%), suggesting a calculation or prevalence error.

Question 4 of 5

What is 'prevalence' in epidemiology?

Correct Answer: B

Rationale: Prevalence (B) is total cases at a time (e.g., 5% diabetes). A is incidence, C is vague, D is mortality.

Question 5 of 5

Which type of study design is most appropriate for establishing a temporal relationship between exposure and outcome?

Correct Answer: C

Rationale: Cohort studies (C) establish temporality by following exposure to outcome (e.g., smoking then cancer). A is retrospective, B is simultaneous, D is group-level.

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