ATI RN
Pediatric Immune Disorder Test Questions Questions
Question 1 of 5
What is the phagocytic defect of chronic granulomatous disease?
Correct Answer: C
Rationale: CGD is caused by an inability to activate the neutrophil respiratory burst, impairing oxidative killing of ingested microbes.
Question 2 of 5
A 5-month-old infant presented with reluctance to feed, lethargy, abdominal distension, and severe gingivitis. The parents are healthy relatives and gave history of non-purulent omphalitis with separation of umbilical stump at the age of 2 months. His peripheral smear showed neutrophil count 24,000/mm3. Of the following, the MOST likely diagnosis is
Correct Answer: D
Rationale: Leukocyte adhesion deficiency causes delayed umbilical cord separation, high neutrophil counts, and non-purulent infections due to impaired migration.
Question 3 of 5
Which of the following Antibodies occurs as a pentameric structure?
Correct Answer: A
Rationale: IgM is the only antibody that naturally occurs as a pentamer, consisting of five monomeric units linked by a J chain, enhancing its ability to bind multiple antigens simultaneously.
Question 4 of 5
Endothelial cells expresses glycoprotein that binds with low affinity to WBCs and helps in their recruitment from blood to tissues
Correct Answer: A
Rationale: E-selectin on endothelial cells binds to sialyl Lewis X on leukocytes, facilitating low-affinity rolling during recruitment.
Question 5 of 5
A medical student wants to perform a study on MACROPHAGES type 1, the best way to get these cells is by
Correct Answer: C
Rationale: M1 macrophages are pro-inflammatory and induced by IFN-γ and LPS stimulation of monocytes, not IL-10 (which promotes M2). Answer provided as C based on immunology.