ATI RN
Lymphatic System and Immunity Test Questions Questions
Question 1 of 5
What is the most abundant complement protein in the human body?
Correct Answer: C
Rationale: C3 is the most abundant complement protein , central to all activation pathways; C1, C2, C4 are less abundant.
Question 2 of 5
What is the purpose of central tolerance induction in the thymus?
Correct Answer: B
Rationale: Central tolerance ensures T cells recognize self-MHC without attacking self ; not just foreign , not attack self , not B cells .
Question 3 of 5
How are B cells activated?
Correct Answer: A
Rationale: B cells need antigen binding to BCRs and T-helper cytokines ; no twin T cells , RBCs , or antibody-macrophage mechanism activate them.
Question 4 of 5
Lymph nodes function as meeting points between antigen-bearing dendritic cells arriving from the tissue and recirculating B and T lymphocytes. Whereas the dendritic cells coming from the tissue enter the lymph node via the afferent lymphatic vessels, the recirculating lymphocytes enter the lymph node:
Correct Answer: C
Rationale: Lymphocytes enter lymph nodes via blood through high endothelial venules ; not lymph , primary organs , or trapping .
Question 5 of 5
Stimulation of the nucleic acid sensing TLRs that reside in endosomal membranes induces the production of a different cytokine response than is produced by stimulation of the plasma membrane TLRs. In part, this distinction is based on the different adapter proteins used by the nucleic acid sensing TLRs, leading to the activation of IRF factors. The cytokine response following stimulation of nucleic acid-sensing TLRs is characterized by production of:
Correct Answer: A
Rationale: Endosomal TLRs (e.g., TLR-3/7/9) produce type I interferon via IRF; TNF-α , peptides , or chemokines are plasma TLR-related.