ATI RN
Safety Pharmacology Across the Lifespan Questions
Question 1 of 5
What is the correct statement concerning noncompetitive antagonism:
Correct Answer: C
Rationale: Rationale for Choice C: In noncompetitive antagonism, the antagonist binds irreversibly to a site different from the agonist binding site, preventing agonist binding. Increasing agonist concentration cannot overcome this as the antagonist blocks the receptor irreversibly. This results in a fixed maximum response. Summary: A: Incorrect. The potency of the drug may change due to noncompetitive antagonism. B: Incorrect. Noncompetitive antagonism does not affect the number of receptors available to bind the agonist. D: Incorrect. Choice C is correct, making this statement wrong.
Question 2 of 5
A33-year-old woman complained to her physician of numbness and tingling in her fingers and toes. The woman had been taking a drug for 1 month to abort headache. Which of the following drugs most likely caused the patient's symptoms?
Correct Answer: C
Rationale: The correct answer is C: Ergotamine. Ergotamine is known to cause vasoconstriction, leading to decreased blood flow to extremities, resulting in numbness and tingling. Ibuprofen is a nonsteroidal anti-inflammatory drug and does not typically cause numbness and tingling. Valproic acid is used for epilepsy and mood disorders. Propranolol is a beta-blocker used for hypertension and migraines but is not associated with numbness and tingling in extremities.
Question 3 of 5
A2-year-old boy was brought to the emergency department with high body temperature (104°F, 40°C), flushed and dry skin, and widely dilated pupils unresponsive to light. He was agitated and underwent a brief tonic-clonic convulsion. His mother stated that the boy apparently swallowed several tablets of her allergy medication. Which of the following drugs most likely caused the patient's poisoning?
Correct Answer: B
Rationale: The correct answer is B: Diphenhydramine. Diphenhydramine is a first-generation antihistamine that can cause anticholinergic toxicity in overdose. The symptoms described in the question such as high body temperature, dry skin, dilated pupils, and agitation are consistent with anticholinergic poisoning. Diphenhydramine also has sedative effects which can lead to seizures in high doses. A: Ibuprofen is a nonsteroidal anti-inflammatory drug and overdose typically presents with symptoms like gastrointestinal upset and kidney injury, not the symptoms described in the question. C: Phenylephrine is a decongestant that can cause hypertension and tachycardia in overdose, not the symptoms described in the question. D: Celecoxib is a selective COX-2 inhibitor used as an NSAID and overdose usually presents with gastrointestinal symptoms, not the symptoms described in the question.
Question 4 of 5
What kind of substances can't permeate membranes by passive diffusion?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Correct statements listing characteristics of a particular route of drug administration include all of the following EXCEPT:
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.