ATI RN
ATI Pharmacology Practice B Questions
Question 1 of 5
What is the action of Metformin?
Correct Answer: D
Rationale: Metformin is a medication commonly used to treat type 2 diabetes. It exerts its action through multiple mechanisms, as outlined below:
Question 2 of 5
A 33-year-old female is brought to the emergency department by her mother. The patient had a sudden onset of fever and her temperature is now 40°C (104°F). She has no sick contacts. The mother mentions that she is on a medication for schizophrenia but could not remember the name. A complete blood count shows 250 neutrophils per microliter. Which of the following medications is she likely taking?
Correct Answer: A
Rationale: Fever and severe neutropenia (250 neutrophils/μL) in a schizophrenic patient suggest clozapine . Clozapine causes agranulocytosis, a rare but serious side effect requiring monitoring. Olanzapine , Quetiapine , Risperidone , and Haloperidol (E) rarely cause this. Clozapine's risk explains the acute presentation, necessitating immediate cessation.
Question 3 of 5
This drug when taken orally reverses the hepatic necrosis effect of paracetamol :
Correct Answer: D
Rationale: Acetylcysteine is the antidote for acetaminophen (paracetamol) overdose. Acetaminophen overdose can lead to hepatic necrosis, and acetylcysteine is effective in preventing or reversing this hepatotoxicity. It works by replenishing depleted hepatic stores of glutathione, which is essential for detoxifying the reactive metabolite of acetaminophen. This helps to protect the liver cells from damage caused by the toxic metabolite of acetaminophen. Naloxone, vitamin K, warfarin, and diphenhydramine are not effective in reversing the hepatic necrosis caused by paracetamol overdose.
Question 4 of 5
Which of the following is used to calculate the loading dose of a drug required to reach an initial target blood concentration
Correct Answer: D
Rationale: The loading dose of a drug required to reach an initial target blood concentration is based on the volume of distribution (Vd) of the drug. The volume of distribution represents the theoretical volume that would be necessary to contain the total amount of the administered drug at the same concentration as in the blood plasma. The loading dose is calculated by multiplying the target blood concentration by the volume of distribution of the drug. This initial dose helps to rapidly achieve the desired drug concentration in the body, especially when a drug has a long half-life or when steady-state levels need to be reached more quickly. Understanding the volume of distribution of a drug is crucial in dosage calculation to ensure therapeutic efficacy and avoid potential toxicity.
Question 5 of 5
While on pentamidine (Pentam) infusion therapy. The nurse must anticipate doing which of the following?
Correct Answer: B
Rationale: Pentamidine (Pentam) infusion therapy is associated with potential ocular toxicities, including retinal damage. Therefore, the nurse must closely monitor the client for signs and symptoms of retinal damage during the therapy. These may include changes in visual acuity, blurred vision, floaters, or any other visual disturbances. Timely detection of retinal damage is crucial for preventing further complications and ensuring appropriate management.