What is the action of Metformin?

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: D

Rationale: Lithium is commonly used in the treatment of bipolar disorder. One of the expected outcomes of lithium treatment is a decreased incidence of acute manic episodes. Lithium helps stabilize mood and reduce the frequency and severity of manic episodes in patients with bipolar disorder. It is considered one of the first-line treatments for managing symptoms of mania in bipolar disorder. While lithium has various physiological effects in the body, its primary use in mental health is to manage mood symptoms associated with bipolar disorder, particularly the manic phase. Therefore, the expected outcome of lithium treatment is a decrease in the incidence of acute manic episodes.

Correct Answer: C

Rationale: Metformin belongs to the pharmacological class known as biguanides. Biguanides are a group of oral medications commonly used to treat type 2 diabetes by lowering blood sugar levels. Metformin works primarily by decreasing the production of glucose in the liver while also increasing the sensitivity of muscle cells to insulin. This class of drugs does not stimulate insulin release from the pancreas like sulfonylureas and meglitinides but rather works by targeting the liver and improving insulin sensitivity in peripheral tissues. The main pharmacological effect of metformin is to reduce hepatic glucose output, which helps to control blood glucose levels in individuals with type 2 diabetes.

Correct Answer: C

Rationale: Lithium is a mood stabilizer used primarily in the treatment of bipolar disorder. It helps to reduce the intensity and frequency of manic episodes in patients with bipolar disorder, as well as prevent the recurrence of both manic and depressive episodes. Lithium is not classified as an anti-diabetic, anti-ulcer agent, or diuretic.

Correct Answer: A

Rationale: Bioavailability is defined as the fraction of drug that reaches systemic circulation in an unchanged form after administration. It is a crucial pharmacokinetic parameter that reflects the amount and rate of drug absorption. Bioavailability can be influenced by various factors such as the route of administration, drug formulation, and first-pass metabolism. Monitoring bioavailability is important in determining the efficacy and dosage requirements of a drug.