What is one of the therapeutic uses of Valporate?

Correct Answer: A

Rationale: Valproate, commonly known as sodium valproate or valproic acid, is a medication primarily used to treat seizures, including epilepsy. It is an antiepileptic drug that works by increasing the levels of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to calm excessive electrical activity that can lead to seizures. Valproate is considered a first-line treatment for various types of seizures, especially absence seizures and generalized tonic-clonic seizures. It is not used for replacing hormones, maintaining blood glucose levels, or lowering blood pressure.

Correct Answer: C

Rationale: Protamine sulfate is a medication that can antagonize the anticoagulant effects of heparin. Heparin works by binding to antithrombin III to enhance its activity, which leads to the inhibition of factor Xa and thrombin. Protamine sulfate, a positively charged molecule, binds to heparin to form a stable complex, neutralizing the anticoagulant effects of heparin. This makes protamine sulfate a useful antidote for heparin overdose or in situations where rapid reversal of heparin is necessary to reduce the risk of bleeding complications. The other options listed - acetylcysteine, naloxone, warfarin sodium, and phenindione - do not have a direct antagonistic effect on the anticoagulant effects of heparin.

Correct Answer: C

Rationale: When a drug is administered by continuous intravenous infusion, it will take approximately 4-5 half-lives for it to reach 90% of its final steady-state level. In this case, the drug has a half-life of 12 hours, so it will take 4 half-lives (12 hours x 4 = 48 hours) for the drug to reach 90% of its final steady-state level. Therefore, the drug will reach 90% of its final steady-state level after 48 hours of continuous infusion.

Correct Answer: C

Rationale: Amphotericin B is an antifungal medication that can cause nephrotoxicity, leading to decreased urine output and renal impairment. Patients should be instructed to report any changes in urinary output promptly. Changes in sight and hearing are not typical adverse effects of amphotericin B. A painful red rash and blisters may indicate an allergic reaction but are less common than nephrotoxicity.

Correct Answer: B

Rationale: Adrenergic blockers can affect labor, and babies born to mothers taking these drugs may exhibit adverse cardiovascular, respiratory, and CNS effects. Problems with the GI and GU systems have not been reported. The nurse should monitor the newborn for potential adverse effects and intervene as needed to ensure safety.