ATI RN
Advanced Pharmacology Across the Lifespan Questions
Question 1 of 5
What do drug blood levels indicate?
Correct Answer: D
Rationale: The correct answer is D because drug blood levels indicate if the amount of drug in the body is within a therapeutic range, ensuring the drug is effective and safe. Choice A is incorrect because blood levels do not confirm the drug's specific form. Choice B is incorrect as body fat does not directly relate to drug metabolism. Choice C is incorrect as blood levels do not verify medication ownership.
Question 2 of 5
Which of the following enzymes most likely mediated the therapeutic effect of terbinafine in the patient's disease?
Correct Answer: C
Rationale: The correct answer is C: Squalene epoxidase. Terbinafine is an antifungal drug that inhibits squalene epoxidase, a key enzyme in the ergosterol biosynthesis pathway in fungi. Inhibition of squalene epoxidase disrupts fungal cell membrane synthesis, leading to cell death. Thymidylate synthase (A) is involved in DNA synthesis, not the target of terbinafine. Lanosterol synthetase (B) is not a direct target of terbinafine. Transpeptidase (D) is an enzyme targeted by antibiotics like penicillin, not terbinafine. In summary, squalene epoxidase is the correct choice as it is the specific target of terbinafine in fungal cells, distinguishing it from the other options.
Question 3 of 5
Which of the following medications is used to treat depression by inhibiting the reuptake of both serotonin and norepinephrine?
Correct Answer: B
Rationale: Step 1: Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI). Step 2: SNRIs work by blocking the reuptake of both serotonin and norepinephrine in the brain. Step 3: By inhibiting the reuptake of these neurotransmitters, duloxetine helps increase their levels in the brain, which can improve mood and alleviate depression. Step 4: Therefore, duloxetine is the correct choice for a medication that treats depression by inhibiting the reuptake of both serotonin and norepinephrine. Summary: A: Fluoxetine is a selective serotonin reuptake inhibitor (SSRI), not affecting norepinephrine. C: Sertraline is also an SSRI, not targeting norepinephrine reuptake. D: Venlafaxine is an SNRI like duloxetine, but it specifically targets serotonin and norepinephrine reuptake, making
Question 4 of 5
A 60-year-old male with chronic pain is prescribed hydrocodone. Hydrocodone works by:
Correct Answer: A
Rationale: Correct Answer: A Rationale: 1. Hydrocodone is an opioid analgesic that belongs to the group of opioids. 2. Opioids like hydrocodone bind to opioid receptors in the brain, spinal cord, and other parts of the body. 3. By binding to these receptors, hydrocodone modulates pain perception and response. 4. This mechanism of action results in the alleviation of pain in individuals. 5. Therefore, choice A is correct as it accurately describes how hydrocodone works. Summary: - Choice B is incorrect as it describes the mechanism of tricyclic antidepressants, not opioids like hydrocodone. - Choice C is incorrect as it refers to the mechanism of action of NSAIDs, not opioids. - Choice D is incorrect as it describes the mechanism of local anesthetics, not opioids.
Question 5 of 5
Which of the following medications is used to reduce symptoms of allergies by blocking histamine receptors?
Correct Answer: D
Rationale: Certainly! The correct answer is D because all three medications, Diphenhydramine, Loratadine, and Cetirizine, are antihistamines that work by blocking histamine receptors. Diphenhydramine is a first-generation antihistamine with sedating effects, Loratadine is a second-generation antihistamine with non-sedating properties, and Cetirizine is also a second-generation antihistamine. Therefore, all of these medications can effectively reduce allergy symptoms by blocking histamine receptors. The other choices are incorrect because each of them individually is a valid antihistamine used for allergy relief.