What action is often recommended to help reduce tolerance to transdermal nitroglycerin therapy?

Correct Answer: D

Rationale: To help reduce tolerance to transdermal nitroglycerin therapy, it is often recommended to remove the patch at bedtime and then apply a new one in the morning. This drug-free period during sleep helps prevent the development of tolerance to nitroglycerin. By allowing the body to have a break from continuous exposure to the drug, the effectiveness of nitroglycerin can be maintained over time.

Correct Answer: D

Rationale: Ondansetron is typically administered orally, commonly in the form of tablets, orally disintegrating tablets, or liquid solution. The medication is absorbed through the gastrointestinal tract when taken orally, making it an effective route of administration for managing nausea and vomiting. SubQ (subcutaneous), sublingual, and buccal routes are not typical routes of administration for ondansetron.

Correct Answer: A

Rationale: Amphetamine overdose causes sympathomimetic toxicity: elevated heart rate (HR) and blood pressure (BP) from catecholamine release, mydriasis via alpha-adrenergic stimulation, and CNS excitation—aggressiveness, paranoia, and hallucinations—due to dopamine and norepinephrine excess. Ethanol overdose typically depresses CNS, causing sedation, not excitation, despite possible tachycardia. Fentanyl, an opioid, leads to respiratory depression and miosis, opposite to these symptoms. Flunitrazepam, a benzodiazepine, sedates and lowers BP. Marijuana might cause paranoia but not this full sympathomimetic profile. Amphetamine's stimulant properties directly explain the cardiovascular, pupillary, and psychiatric symptoms, making it the most likely culprit in this acute presentation.

Correct Answer: A

Rationale: Graded dose-response curves plot individual response intensity to dose increases (e.g., pain relief), a pharmacodynamic tool. Population curves (e.g., ED50) suit groups, not individuals. Large or small groups aggregate data, missing individual nuance. Individual focus defines graded curves, key for tailoring therapy.

Correct Answer: A

Rationale: PCP overdose (triple dose) causes dissociative effects; eyes remain open , with nystagmus common. Loss of consciousness needs higher doses. Numbness occurs, but open eyes are hallmark. Normal gait and speech (E) contradict ataxia. PCP's profile fits this.