Vitamin К enhances the anticoagulant property of coumarins. This statement is:

Correct Answer: B

Rationale: Step 1: Identify the statement - "Vitamin K enhances the anticoagulant property of coumarins." Step 2: Recall that Vitamin K is actually involved in blood clotting, counteracting anticoagulants. Step 3: Understand that coumarins are anticoagulants that work by inhibiting Vitamin K. Step 4: Therefore, the statement is FALSE as Vitamin K doesn't enhance but counteracts coumarins. Summary: Choice A is incorrect because the statement is false, Choice C and D are incorrect as they do not apply to the given scenario.

Correct Answer: A

Rationale: Rationale: A: Correct. Calcitriol regulates calcium and phosphate levels, leading to potential ectopic calcification. Monitoring is crucial. B: Incorrect. Calcitriol does undergo enterohepatic circulation. C: Incorrect. Calcitriol is not toxic to osteoclasts; it has a role in bone health. D: Incorrect. Calcitriol has a complex relationship with bioavailability, affected by several factors.

Correct Answer: C

Rationale: Rationale: Hydrochlorothiazide blocks NaCl cotransporters in the distal tubule, reducing sodium reabsorption and increasing diuresis. Acetazolamide inhibits carbonic anhydrase in the proximal tubule. Furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb. Spironolactone is a mineralocorticoid receptor antagonist acting on the principal cells of the collecting duct. Therefore, the correct answer is C, as it directly targets the distal tubule's mechanism of sodium reabsorption.

Correct Answer: C

Rationale: The correct answer is C: Imipenem, as it belongs to the carbapenem class of antibiotics. Carbapenems are broad-spectrum antibiotics effective against a wide range of bacteria, including some that are resistant to other antibiotics. Imipenem is specifically known for its activity against gram-positive and gram-negative bacteria. A: Aztreonam is a monobactam antibiotic, not a carbapenem. B: Amoxicillin is a penicillin antibiotic, not a carbapenem. D: Clarithromycin is a macrolide antibiotic, not a carbapenem. In summary, only Imipenem (Choice C) is a carbapenem antibiotic, making it the correct choice for this question.

Correct Answer: B

Rationale: The correct answer is B: Isoniazid. It is a first-line antimycobacterial drug used for treating tuberculosis. It targets the mycobacterial cell wall synthesis, specifically inhibiting mycolic acid production. This makes it effective against Mycobacterium tuberculosis. PAS (A) is a second-line drug with a different mechanism. Kanamycin (C) is also a second-line drug used for drug-resistant TB. Pyrazinamide (D) is a first-line drug, but it works by a different mechanism compared to isoniazid.