Correct Answer: C

Rationale: The correct answer is C: Granuloma formation. In response to tuberculosis antigen (tuberculin), the immune system forms a granuloma at the injection site as a defense mechanism. Granulomas are organized collections of immune cells that wall off the antigen and prevent its spread. This process involves macrophages, T cells, and fibroblasts. Choice A (Cells cytotoxity) is incorrect because tuberculin test does not involve direct cell cytotoxicity. Choice B (Reagin type cytotoxity) is incorrect as reagin type hypersensitivity is associated with allergic reactions, not granuloma formation. Choice D (Immunocomplex cytotoxity) is also incorrect as immunocomplex cytotoxicity refers to tissue damage caused by immune complexes, not granuloma formation.

Correct Answer: B

Rationale: The correct answer is B: Hantavirus. Hantaviruses are not arthropod-borne, unlike the other choices. Hantaviruses are transmitted to humans primarily through contact with rodent urine, feces, or saliva. Phlebovirus (A), Nairovirus (C), and Uukuvirus (D) are all bunyaviruses that are transmitted by arthropod vectors such as mosquitoes or ticks. Therefore, Hantavirus is the correct answer as it is not transmitted by arthropods.

Correct Answer: D

Rationale: The correct answer is D because utilizing all three methods—immunofluorescence, viral neutralization reaction, and electron microscopy—provides a comprehensive and rapid diagnosis of various viral infections. Immunofluorescence detects viral antigens directly, viral neutralization reaction demonstrates the presence of specific antibodies, and electron microscopy visualizes viral particles. This combination ensures accurate and quick identification of different viruses. Choices A, B, and C alone may not cover all aspects of viral diagnosis, making them less effective compared to the comprehensive approach of using all three methods.

Correct Answer: C

Rationale: The correct answer is C: Bacillus, Clostridium. Both Bacillus and Clostridium are known to form spores. Bacillus species produce endospores, which are resistant structures for survival in harsh conditions, while Clostridium species also form spores for protection and dispersal. The other choices are incorrect because Borrelia and Treponema are spirochetes and do not form spores, Bacteroides and Fusobacterium are anaerobic bacteria that do not produce spores, and Bordetella and Brucella are non-spore forming bacteria as well.

Correct Answer: B

Rationale: The correct answer is B: Shagreen leather. Yersinia pestis, the bacterium causing plague, forms colonies resembling shagreen leather on a hard nutrient medium due to its distinctive morphology. This morphology includes a rough, irregular, and raised appearance, similar to the texture of shagreen leather. A: Dewdrops - Incorrect. Dewdrops do not accurately describe the colony morphology of Yersinia pestis. C: Lace handkerchief - Incorrect. Lace handkerchief does not accurately describe the colony morphology of Yersinia pestis. D: Mercury drops - Incorrect. Mercury drops do not accurately describe the colony morphology of Yersinia pestis.