ATI RN
NCLEX questions on chemotherapy drugs Questions
Question 1 of 5
Trimethoprim is combined with sulfamethoxazole in a ration of 1:5 to yield a steady state plasma concentration ratio of
Correct Answer: C
Rationale: The 1:5 ratio of trimethoprim to sulfamethoxazole achieves a 1:20 plasma concentration ratio, optimizing synergistic folate inhibition.
Question 2 of 5
Which of the following is not a first line antitubercular drug?
Correct Answer: A
Rationale: Ciprofloxacin is not a first-line TB drug; first-line drugs include isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin.
Question 3 of 5
Which of the following chemotherapy agents acts by intercalation?
Correct Answer: C
Rationale: Doxorubicin intercalates DNA, inhibiting nucleic acid synthesis.
Question 4 of 5
The most important reason for using a combination of chemotherapeutic agents in the treatment of tuberculosis is
Correct Answer: B
Rationale: Preventing resistance is the primary reason for TB combination therapy, targeting different bacterial populations.
Question 5 of 5
According to the currect WHO guidelines new (untreated) sputum smear positive cases of pulmonary tuberculosis are to be treated with the following regimen
Correct Answer: C
Rationale: WHO guidelines recommend 2 months of isoniazid, rifampin, pyrazinamide, and ethambutol/streptomycin, followed by 4 months of isoniazid and rifampin.