ATI RN
RN ATI Capstone Pharmacology 2 Quiz Questions
Question 1 of 5
Trimethoprim:
Correct Answer: B
Rationale: Trimethoprim inhibits dihydrofolate reductase, not activates it, blocking folate synthesis in bacteria, so that's false. It's a weak base, a true statement, aiding its concentration in acidic environments like urine. It has good prostate penetration, effective in prostatitis, making that false. It distributes into CSF, useful in meningitis, so that's incorrect. It's teratogenic, not harmless in pregnancy. Its basic nature enhances its antibacterial efficacy, a key pharmacokinetic advantage in urinary tract infections.
Question 2 of 5
When reading about a drug, the nurse learns it has a median toxic dose of 50 mg. The patient has been receiving 60 mg of the drug. What analysis does the nurse make?
Correct Answer: C
Rationale: Median toxic dose (TD50) is where 50% show toxicity-60 mg exceeds this, raising adverse effect risk (e.g., toxicity signs), not lethality for all. Effect may persist, not fail. Efficacy/potency are defined, just exceeded. Lethal dose (LD50) differs-60 mg isn't half lethal. Excess drives risk, per pharmacodynamics.
Question 3 of 5
The patient receives imipramine (Tofranil) as treatment for depression. He is admitted to the emergency department following an intentional overdose of this medication. What will the priority assessment by the nurse include?
Correct Answer: A
Rationale: Imipramine, a TCA, in overdose risks cardiac toxicity-arrhythmias (e.g., QRS widening)-per toxicology, making heart status priority. Liver and renal function matter but are secondary-cardiac collapse kills faster. Neurological signs (e.g., seizures) follow but heart trumps. Cardiac focus saves lives, per protocol.
Question 4 of 5
A 62-year-old man with Parkinson's disease on levodopa and carbidopa presents to his primary care physician for follow-up. He is following his prescribed course of medications. He is stable in terms of his motor function but recently has begun to have visual and auditory hallucinations. What is the most likely explanation for these findings?
Correct Answer: A
Rationale: Hallucinations in a Parkinson's patient on levodopa/carbidopa suggest a medication-related issue. Drug toxicity is correct-levodopa increases dopamine, and excess in non-motor areas (e.g., mesolimbic) can cause hallucinations, especially with long-term use or dose accumulation. Overactivity at basal ganglia improves motor symptoms, not hallucinations. Subtherapeutic dosing would worsen motor control, not cause this. Dementia or infection (E) could contribute, but hallucinations align more with levodopa's known side effect profile. Carbidopa reduces peripheral effects, but central dopamine excess remains possible, making toxicity the likely culprit in this stable motor context.
Question 5 of 5
A 37-year-old woman is brought to the emergency department by a friend after consuming an entire month's supply of amitriptyline. She is tachycardic, drowsy, nauseous, and has a headache. Which of the following could the physician administer to help this patient?
Correct Answer: A
Rationale: Amitriptyline overdose (TCA) causes anticholinergic and cardiac toxicity. Bicarbonate corrects acidosis and stabilizes sodium channels, reducing arrhythmias. Dimercaprol , Methylene blue , and Vitamin K (E) are irrelevant. Naloxone treats opioids. Bicarbonate's role in TCA overdose is critical for this presentation.