Tolcapone is an antiparkinsonian agent that inhibits which of the following enzymes in brain?

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Question 1 of 5

Tolcapone is an antiparkinsonian agent that inhibits which of the following enzymes in brain?

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 2 of 5

A 56-year-old male is on numerous medications, many of which are metabolized by the cytochrome P-450 system. He went to the psychiatric with depression. Given his multiple medications, which of the following antidepressant drugs should be avoided?

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 3 of 5

Which of the following drugs, is an insulin sensitizer:

Correct Answer: B

Rationale: Rosiglitazone (choice B), a thiazolidinedione, enhances insulin sensitivity by activating PPAR-γ receptors, improving glucose uptake in muscle and fat, ideal for type 2 diabetes. Chlorpropamide (choice A), Glipizide (choice C), and Glyburide (choice D), sulfonylureas, stimulate insulin secretion, not sensitivity. Rosiglitazone's sensitizing action contrasts with secretagogues, addressing insulin resistance without hypoglycemia risk. This mechanism is critical for patients with metabolic syndrome, though its use is limited by side effects like fluid retention, requiring careful patient selection.

Question 4 of 5

A young woman was diagnosed to have endometriosis. The most appropriate therapy for this patient would be:

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 5 of 5

All the following are complications of large doses of glucocorticoids, EXCEPT:

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

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