Tick the drug used for malaria chemoprophylaxis and treatment:

Correct Answer: A

Rationale: Certainly! Chloroquine is the correct answer for malaria chemoprophylaxis and treatment because it is effective against Plasmodium species. It acts by accumulating in the parasite's food vacuole, interfering with heme polymerization. This prevents the parasite from utilizing hemoglobin and ultimately leads to its death. Quinidine and quinine are primarily used for severe malaria treatment. Sulfonamides are not commonly used for malaria treatment due to resistance issues and their limited efficacy against Plasmodium species.

Correct Answer: D

Rationale: Correct Answer: D Rationale: 1. Hypermagnesemia can exacerbate heart failure. 2. Vomiting may further worsen magnesium levels. 3. Digoxin toxicity is a concern in hypermagnesemia. 4. Discontinuing digoxin is crucial to avoid adverse effects. 5. Starting losartan can help manage heart failure without worsening hypermagnesemia. Summary: A: Adding potassium may worsen hypermagnesemia. B: Atropine is not indicated for hypermagnesemia or heart failure. C: Increasing furosemide may lead to electrolyte imbalances. D: Discontinuing digoxin and starting losartan is the appropriate therapeutic adjustment.

Correct Answer: A

Rationale: The correct answer is A: By binding to fibrin. Plasminogen is converted into active plasmin by binding to fibrin through the tissue plasminogen activator (tPA). This binding triggers the activation of plasminogen into plasmin, which then degrades fibrin clots. The other choices (B: collagen, C: heparin, D: platelets) are incorrect because plasminogen activation specifically involves binding to fibrin to initiate the fibrinolytic cascade. Collagen, heparin, and platelets do not play a direct role in the conversion of plasminogen to plasmin.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.