ATI RN
Safety Pharmacology Across the Lifespan Questions
Question 1 of 5
Tick the anticancer drug of plant origin:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
A patient is presented with weakness of legs, arms, trunk, tingling and numbness that progressively worsens. Peripheral blood smear shows macrocytic anemia. Which of the following is not the factor causing this condition?
Correct Answer: D
Rationale: The symptoms (weakness, tingling, numbness) and macrocytic anemia suggest vitamin B12 deficiency, often causing subacute combined degeneration of the spinal cord. Chronic atrophic gastritis (A), ileal resection (B), tapeworm infestation (C), and alcoholism (D) all impair B12 absorption or metabolism. Exposure to nitrous oxide (E) inactivates B12, causing similar symptoms, but it’s an external factor, not a chronic condition like the others, making it the least fitting as a 'factor causing this condition.'
Question 3 of 5
A patient is presented with pallor, fatigue and dyspnea. Physical examination shows koilonychias and angular cheilosis. Which of the following is not expected in the laboratory finding of this patient?
Correct Answer: B
Rationale: Pallor, fatigue, dyspnea, koilonychias (spoon nails), and angular cheilosis suggest iron deficiency anemia. Expected lab findings include low serum ferritin (D), low iron:TIBC ratio (C), and high total iron binding capacity (TIBC) due to increased transferrin production. Low TIBC (A) is not typical; TIBC is usually elevated in iron deficiency. High serum transferrin (B) is expected, as transferrin increases to bind scarce iron, making B the *not expected* finding if misinterpreted as abnormal—however, it’s typically high, so A is the outlier.
Question 4 of 5
RBCs break into fragments, they are referred to as schistocytes. These type of cells are seen in
Correct Answer: C
Rationale: Schistocytes (fragmented RBCs) are hallmark of microangiopathic hemolytic anemia (MAHA, B), e.g., TTP or DIC, due to mechanical shearing. Thalassemia (A) shows target cells, ITP (C) is thrombocytopenia without schistocytes, Gilbert’s syndrome (D) is benign hyperbilirubinemia—MAHA fits. Note: C seems a typo for B based on options.
Question 5 of 5
What’s the most appropriate test to diagnose haemophilia?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.