ATI RN
Pharmacology Across the Lifespan Questions
Question 1 of 5
Tick the anticancer alkylating drug, a derivative of ethylenimine:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
Which of the following is false regarding heparin?
Correct Answer: A
Rationale: Heparin is an anticoagulant with several true properties: it binds to antithrombin III to inhibit thrombin (C), protamine sulfate reverses its effects (D), and partial thromboplastin time monitors its use (E, implied). Subcutaneous injection can cause hematomas, but it’s not avoided—it’s a common administration route (A is true). Heparin is not 'stored' in mast cells (B); it’s produced by mast cells and basophils but released, not stored, making B false.
Question 3 of 5
The typical Reed-Sternberg cells are either infrequent or absent. Instead, lymphocytic and histiocytic cells or 'popcorn cells' are seen within a background of inflammatory cells, which are predominantly benign lymphocytes. Which type of Hodgkin’s lymphoma best suit the description?
Correct Answer: D
Rationale: Lymphocyte predominance (D) Hodgkin’s lymphoma features 'popcorn cells' (lymphocytic and histiocytic cells) instead of classic Reed-Sternberg cells, with a lymphocyte-rich background and excellent prognosis. Nodular sclerosis (A) has classic RS cells, mixed cellularity (B) has frequent RS cells, lymphocyte depleted (C) is aggressive with RS cells, and lymphocyte-rich (E) has RS cells—only D matches the description.
Question 4 of 5
Graft versus host disease is a complication of transfusion in patients of bone marrow transplantation. This can be best avoided by
Correct Answer: B
Rationale: Graft-versus-host disease (GVHD) occurs when donor lymphocytes attack the recipient. Irradiating blood components (B) inactivates lymphocytes, preventing GVHD in bone marrow transplant patients. Packed cells (A) or fresh blood (C) don’t eliminate lymphocytes, crystalloids (D) aren’t transfusions, and relative donors (E) increase risk—irradiation is standard.
Question 5 of 5
In the laboratory diagnosis of leishmaniasis, the expected parasite stage in vitro is
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.