ATI RN
Pediatric Immunization NCLEX Questions Quizlet Questions
Question 1 of 5
This parasite (Onchcerca volvulus) lives outside its host's cells (extracellular); therefore, cytotoxic T cells (CTLs) are ineffective in clearing the organism. This inability on the part of CTLs is due to their requirement to engage which of the following surface structures for their cytotoxic activity?
Correct Answer: B
Rationale: Cytotoxic T cells (CTLs) target intracellular pathogens by recognizing antigens presented on MHC class I molecules. Since Onchocerca volvulus is extracellular, CTLs are ineffective as they cannot engage MHC class I-peptide complexes in this context.
Question 2 of 5
Which of the following have not provided examples of secondary immunodeficiency?
Correct Answer: D
Rationale: High fat diet is not a well-documented cause of secondary immunodeficiency, unlike viral infections (e.g., HIV), lymphoproliferative disorders, or cytotoxic drugs.
Question 3 of 5
Which of the following isotypes of antibodies activate the complement cascade if bound to antigen?
Correct Answer: D
Rationale: IgM and IgG effectively activate the complement cascade via the classical pathway when bound to antigens.
Question 4 of 5
An article published in the Oncoimmunology journal in September 2018. It is discussing an immunotherapy approach that relies on designing and infecting the cancer patient two viruses expressing Melanoma-associated antigen A3 (MAGE-A3). The two viruses, a replication-deficient type-5 human adenoviral (Ad-MAGEA3) and Maraba MGI rhabdovirus(MGI-MAGEA3), are studied in this article preclinically by infecting nonhuman primates(monkeys). This immunotherapy approach is considered:
Correct Answer: A
Rationale: Using viruses to express tumor antigens like MAGE-A3 to stimulate an immune response classifies this as a vaccination strategy in cancer immunotherapy.
Question 5 of 5
Matching: Complement deficiency - Nonpitting edema
Correct Answer: D
Rationale: C1 inhibitor deficiency causes hereditary angioedema, characterized by nonpitting edema due to unregulated bradykinin production. Other complement deficiencies do not typically present with this feature.