ATI RN
ABVD chemotherapy drugs Questions
Question 1 of 5
This drug can clear trypanosomes from the blood and lymph nodes and is active in the late CNS stages of African sleeping sickness.
Correct Answer: B
Rationale: Melarsoprol crosses the blood-brain barrier and is effective against late-stage African trypanosomiasis (sleeping sickness) in the CNS.
Question 2 of 5
Which one of the following is least likely to be a mechanism of cancer cell resistance to antineoplastic drugs?
Correct Answer: B
Rationale: Decreased activity of activating enzymes is less common as a resistance mechanism compared to the others listed, which are well-documented.
Question 3 of 5
Cyclosporine is effective in organ transplantation. The immunosuppressant action of the drug appears to be due to
Correct Answer: D
Rationale: Cyclosporine inhibits interleukin gene transcription (e.g., IL-2) by blocking calcineurin, suppressing T-cell activation in transplantation.
Question 4 of 5
Which one of the following agents acts at the step of antigen recognition?
Correct Answer: D
Rationale: Rh0 (D) immune globulin prevents antigen recognition by coating Rh-positive fetal RBCs, blocking maternal immune response.
Question 5 of 5
Which one of the following agents increases phagocytosis by macrophages in patients with chronic granulomatous disease?
Correct Answer: B
Rationale: Interferon-γ enhances macrophage phagocytosis in chronic granulomatous disease by boosting immune function.