ATI RN
Virtual ATI Pharmacology Assessment Questions
Question 1 of 5
The ulcerogenic properties of aspirin is caused by the following, except
Correct Answer: B
Rationale: The ulcerogenic properties of aspirin are primarily caused by the inhibition of prostaglandin synthesis, particularly through the inhibition of the enzyme cyclooxygenase-1 (Cox-1). Prostaglandins play a crucial role in maintaining the protective mucus barrier in the stomach lining. When prostaglandin synthesis is inhibited, this protective barrier is compromised, leading to increased susceptibility to damage from the acidic gastric environment. The drug's acidity itself (Choice A), by irritating the stomach lining, can contribute to ulcer formation. Thromboxane inhibition (Choice B) is not directly related to the ulcerogenic properties of aspirin but is more associated with the drug's antiplatelet effects. Cox-1 inhibition (Choice D) is a key factor in aspirin-induced gastrointestinal injury as it disrupts the normal mucosal defense mechanisms.
Question 2 of 5
The nursing mother asks the nurse if it is all right to take St. John's wort for mild depression. What is the best response by the nurse?
Correct Answer: C
Rationale: St. John's wort, an herbal antidepressant, passes into breast milk, potentially affecting the baby-e.g., sedation or colic-making it unsafe without medical advice. Allergies lack evidence as a concern. Milk production isn't a known issue. Taste changes are unproven. Excretion risk is the primary concern, supported by pharmacokinetics, prioritizing infant safety.
Question 3 of 5
What route is Amlodipine taken?
Correct Answer: A
Rationale: Amlodipine is a medication that is taken orally, usually in the form of tablets. The abbreviation "PO" stands for per os, which means by mouth or orally. Amlodipine is widely prescribed to treat high blood pressure and certain types of chest pain. It works by relaxing the blood vessels, making it easier for the heart to pump blood. Taking amlodipine orally allows it to be absorbed through the digestive system and enter the bloodstream to exert its therapeutic effects.
Question 4 of 5
The apparent volume of distribution:
Correct Answer: A
Rationale: A high apparent volume of distribution indicates extensive tissue binding or fat solubility, often exceeding total body water or blood volume.
Question 5 of 5
Which activity has a higher priority for the nurse to advise the patient to avoid while taking ixazomib?
Correct Answer: C
Rationale: Ixazomib, a proteasome inhibitor, can cause myelosuppression, increasing the risk of infections. Patients should be advised to avoid crowds and individuals who are ill to reduce exposure to infectious agents. While alcohol and aspirin may interact with other medications, they are not specifically contraindicated with ixazomib. Taking the drug on an empty stomach is not required, as it can be taken with or without food. Preventing infections is the highest priority due to the drug's impact on the immune system.