ATI RN
Pediatric Immunization Test Questions Questions
Question 1 of 5
The thymus is the primary site of T-cell development. Which of the following is the correct order arranged from the area with the earliest progenitor cells to the area with the most mature T lymphocytes?
Correct Answer: D
Rationale: T cell maturation progresses from subcapsular zone (progenitors) to cortex to medulla (mature T cells).
Question 2 of 5
During B cell development, when is there rearrangement in the light (L) chain of the immunoblobulin gene started?
Correct Answer: C
Rationale: Light chain rearrangement starts in the late pre-B cell stage.
Question 3 of 5
A young child undergoes implantation of a cardiac pacemaker. During surgery, the physician must remove the thymus. If this child encounters an antigen requiring B-cell-Tcell collaboration, they will to mount an immune response. These antigens are thus called
Correct Answer: C
Rationale: Thymectomy prevents T cell development, impairing responses to thymus-dependent antigens.
Question 4 of 5
Approximately how many cells survive the selection process?
Correct Answer: D
Rationale: Only about 5% of T cells survive the rigorous positive and negative selection in the thymus.
Question 5 of 5
Antigens and lymphoid cells are delivered to the secondary lymphoid tissues (spleen, lymph nodes) via:
Correct Answer: D
Rationale: Dendritic cells are key antigen-presenting cells delivering antigens to secondary lymphoid tissues.