The side effect of interferon gamma is:

Correct Answer: D

Rationale: Interferon gamma is associated with the side effect of fatigue due to its immunomodulatory effects causing systemic symptoms. This side effect is commonly reported in patients receiving interferon therapy. Hypertension, pulmonary edema, and nephrotoxicity are not typically linked to interferon gamma therapy. Thus, the correct answer is D.

Correct Answer: A

Rationale: The correct answer is A because drug combinations are likely synergistic when they target different steps in the same pathway, resulting in additive or synergistic effects. This increases efficacy and reduces side effects. Choice B is incorrect as the statement is true. Choices C and D are incorrect as they are not valid options in this context.

Correct Answer: D

Rationale: The correct answer is D because cholecalciferol, also known as vitamin D3, exerts its effects through genomic effects (regulating gene expression) and cytoplasmic effects (regulating calcium transport). This is crucial for its role in calcium homeostasis and bone health. A is incorrect because cholecalciferol is typically administered orally and does not require frequent monitoring of calcium and phosphorus serum levels. B is incorrect because cholecalciferol promotes bone formation by enhancing osteoblast activity, not inhibiting osteoclasts. C is incorrect because cholecalciferol actually helps increase serum calcium levels by enhancing calcium absorption in the intestines and promoting calcium reabsorption in the kidneys, rather than lowering them.

Correct Answer: C

Rationale: Sustained use of furosemide and acetazolamide can lead to increased plasma urate concentrations. Furosemide inhibits uric acid secretion, while acetazolamide impairs renal excretion of uric acid. Therefore, both drugs can result in elevated plasma urate levels. Choice C is correct. Choice A is incorrect because furosemide does not decrease plasma urate concentrations. Choice B is incorrect because acetazolamide does not lower plasma urate concentrations. Choice D is incorrect as both drugs can increase plasma urate levels.

Correct Answer: C

Rationale: The correct answer is C: Clindamycin. Clindamycin is not an aminoglycoside; it belongs to the lincosamide class. Gentamicin, Streptomycin, and Neomycin are aminoglycosides. Aminoglycosides are characterized by their mechanism of action involving binding to the bacterial ribosome, leading to inhibition of protein synthesis. Clindamycin, on the other hand, acts by inhibiting bacterial protein synthesis at a different site. Therefore, Clindamycin does not belong to the aminoglycoside group.